{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T20:48:39Z","timestamp":1764362919707},"reference-count":57,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T00:00:00Z","timestamp":1437696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"King Hussein Cancer Center","award":["13KHCC23"],"award-info":[{"award-number":["13KHCC23"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:p>Atypical teratoid\/rhabdoid tumor (AT\/RT) is a rare tumor of the CNS mostly seen in infants and is often associated with a dismal outcome. Despite the heterogeneous morphology and\/or immunoprofile, its diagnosis nowadays relies on the negative INI\u20101\/BAF47 nuclear immunostain in tumor cells. We aim to investigate a number of immunohistochemical antibodies as potential diagnostic and prognostic markers. All AT\/RT cases in patients younger than 18 years of age were included. Demographics, clinical features and outcome were collected. Immunostains tested included SALL\u20104, OCT3\/4, CD99, FLI\u20101, cyclin\u2010D1, \u03b2\u2010catenin, P53, P16, CDX2 and WT\u20101. Nineteen cases (10 males) were identified at our center between 2004\u20102013 with a median age of 24 months. Ten (52.6%) cases were supratentorial. Six (42.9%) cases showed metastasis at time of presentation. Chemotherapy was administered to 10 (62.5%) and radiotherapy to seven (43.8%). The median overall survival was 11 months. A single long\u2010term survival of 104 months was identified. Pathologically, most cases showed an admixture of rhabdoid cells and\/or small cells and\/or pale cells in variable proportions. Of all tested antibodies, only positivity for FLI\u20101 was associated with improved survival (<jats:italic>P<\/jats:italic> = 0.0012), while positivity for cyclin\u2010D1 showed a trend toward improved survival (<jats:italic>P<\/jats:italic> = 0.0547). CDX2 was positive only in the single long\u2010term survival. Interestingly, two cases showed co\u2010expression of CD99 and FLI\u20101, and some were positive for SALL\u20104. In conclusion, FLI\u20101 and cyclin\u2010D1 are potential prognostic markers associated with better outcome. Occasional AT\/RT cases might co\u2010express CD99 and FLI\u20101 as well as SALL\u20104, a potential diagnostic pitfall with Ewing sarcoma\/ primitive neuroectodermal tumors and germ cell tumors, respectively.<\/jats:p>","DOI":"10.1111\/neup.12231","type":"journal-article","created":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T09:16:33Z","timestamp":1437729393000},"page":"17-26","source":"Crossref","is-referenced-by-count":10,"title":["Atypical teratoid\/ rhabdoid tumor, an immunohistochemical study of potential diagnostic and prognostic markers"],"prefix":"10.1111","volume":"36","author":[{"given":"Maysa","family":"Al\u2010Hussaini","sequence":"first","affiliation":[{"name":"Departments of Pathology King Hussein Cancer Center (KHCC)  Amman Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noreen","family":"Dissi","sequence":"additional","affiliation":[{"name":"Departments of Pathology King Hussein Cancer Center (KHCC)  Amman 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