{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:52:53Z","timestamp":1777467173196,"version":"3.51.4"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T00:00:00Z","timestamp":1446768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:p>In sporadic Creutzfeldt\u2010Jakob disease (sCJD), high signal intensity in fluid attenuated inversion recovery (FLAIR) and diffusion\u2010weighted imaging (DWI) sequences in striatum and\/or cortical regions of the brain are present in about 83% of cases, reflecting tissue damage, such as spongiform change and abnormal prion protein deposits. Novel diffusion sequences of MRI might improve the detection of CJD characteristic changes in the subset of patients in whom these alterations are absent or less evident. We report a neuropathologically confirmed case of the rare MM2 T\u2009+\u2009C subtype of sCJD, with mixed clinical and neuropathological features of MM2 thalamic and MM2 cortical subtypes, in whom the use of diffusion tensor imaging helped to identify cortical hyperintensities that could be easily overlooked with conventional DWI.<\/jats:p>","DOI":"10.1111\/neup.12261","type":"journal-article","created":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T07:02:45Z","timestamp":1446793365000},"page":"199-204","source":"Crossref","is-referenced-by-count":11,"title":["Sporadic MM2\u2010thalamic\u2009+\u2009cortical Creutzfeldt\u2010Jakob disease: Utility of diffusion tensor imaging in the detection of cortical involvement <i>in vivo<\/i>"],"prefix":"10.1111","volume":"36","author":[{"given":"Oriol","family":"Grau\u2010Rivera","sequence":"first","affiliation":[{"name":"Neurological Tissue Bank of the Biobanc\u2010Hospital Cl\u00ednic\u2010Institut d'Investigacions Biom\u00e8diques August Pi I Sunyer (IDIBAPS)  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"S\u00e1nchez\u2010Valle","sequence":"additional","affiliation":[{"name":"Alzheimer disease and other cognitive disorders Unit, Department of Neurology Hospital Cl\u00ednic, IDIBAPS  Barcelona Spain"},{"name":"Department of Neurology Hospital Cl\u00ednic. IDIBAPS  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuria","family":"Bargall\u00f3","sequence":"additional","affiliation":[{"name":"Radiology Department Image Diagnosis Center, Hospital Cl\u00ednic  Barcelona Spain"},{"name":"Magnetic Resonance Image core facility of IDIBAPS  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Llad\u00f3","sequence":"additional","affiliation":[{"name":"Alzheimer disease and other cognitive disorders Unit, Department of Neurology Hospital Cl\u00ednic, IDIBAPS  Barcelona Spain"},{"name":"Department of Neurology Hospital Cl\u00ednic. IDIBAPS  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carles","family":"Gaig","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital Cl\u00ednic. 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