{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:58:05Z","timestamp":1790366285299,"version":"4.1.0"},"reference-count":70,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T00:00:00Z","timestamp":1446768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Scientific Research Projects Commission of the G\u00fcm\u00fc\u015fhane Univesity","award":["13.B0421.02.02"],"award-info":[{"award-number":["13.B0421.02.02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p><jats:italic>Toxoplasma gondii<\/jats:italic> (<jats:italic>T<\/jats:italic>. <jats:italic>gondii<\/jats:italic>) is a protozoan parasite with the potential of causing severe encephalitis among immunocompromised humans and animals. Our previous study showed that <jats:italic>T<\/jats:italic>. <jats:italic>gondii<\/jats:italic> induces high nitric oxide (NO) production, high glial activation (GFAP) and neurofilament expressions, leading to severe neurodegeneration in toxoplasma encephalitis (TE) in the central nervous system (CNS). The aim of this experimental study was to investigate ADAMTS\u201013 expression and apoptosis in CNS and to identify whether they have any correlation with toxoplasmosis neuropathology and neurodegeneration. Mice were infected with ME49 strain <jats:italic>T<\/jats:italic>. <jats:italic>gondii<\/jats:italic> and the levels of ADAMTS\u201013, caspase 3, caspase 8, caspase 9, TNFR1 and Bcl\u2010xL expressions were examined in brain tissues by immunohistochemistry, during the development and establishment of chronic infections at 10, 30 and 60\u2009days post\u2010infection. Results of the study revealed that the levels of ADAMTS\u201013 (<jats:italic>P<\/jats:italic> &lt; 0.005), caspase 3 (<jats:italic>P<\/jats:italic> &lt; 0.05), caspase 8 (<jats:italic>P<\/jats:italic> &lt; 0.05), caspase 9 (<jats:italic>P<\/jats:italic> &lt; 0.005) and TNFR1 (<jats:italic>P<\/jats:italic> &lt; 0.05) expressions in the brain markedly increased while Bcl\u2010xL expression decreased (<jats:italic>P<\/jats:italic> &lt; 0.005). The most prominent finding from our study was that 10, 30 and 60\u2009days post\u2010infection ADAMTS\u201013 increased significantly and this may play an important role in the regulation and protection of the blood\u2010brain barrier integrity and CNS microenvironment in TE. These results also suggest that <jats:italic>T<\/jats:italic>. <jats:italic>gondii<\/jats:italic>\u2010mediated apoptosis might play a pivotal role and a different type of role in the mechanism of neurodegeneration and neuropathology in the process of TE. Furthermore, expression of ADAMTS\u201013 might give an idea of the progress and is critical for diagnosis of this disease. To the best of the authors' knowledge, this is the first report on ADAMTS\u201013 expression in the CNS of <jats:italic>T<\/jats:italic>. <jats:italic>gondii<\/jats:italic>\u2010infected mice.<\/jats:p>","DOI":"10.1111\/neup.12263","type":"journal-article","created":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T06:52:40Z","timestamp":1446792760000},"page":"211-226","source":"Crossref","is-referenced-by-count":29,"title":["Increased expressions of ADAMTS\u201013 and apoptosis contribute to neuropathology during <i>Toxoplasma gondii<\/i> encephalitis in mice"],"prefix":"10.1111","volume":"36","author":[{"given":"Gungor Cagdas","family":"Dincel","sequence":"first","affiliation":[{"name":"Gumushane University Siran Mustafa Beyaz Vocational High School  Gumushane Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan Tarik","family":"Atmaca","sequence":"additional","affiliation":[{"name":"Kirikkale University Faculty of Veterinary Medicine, Department of 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