{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T19:21:48Z","timestamp":1789932108691,"version":"4.0.1"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,11,13]],"date-time":"2015-11-13T00:00:00Z","timestamp":1447372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"JSPS KAKENHI","award":["26430049"],"award-info":[{"award-number":["26430049"]}]},{"name":"JSPS KAKENHI","award":["26430050"],"award-info":[{"award-number":["26430050"]}]},{"name":"JSPS KAKENHI","award":["26860655"],"award-info":[{"award-number":["26860655"]}]},{"name":"JSPS KAKENHI","award":["24300131"],"award-info":[{"award-number":["24300131"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p>Accumulation of phosphorylated \u03b1\u2010synuclein in neurons and glial cells is a histological hallmark of Lewy body disease (LBD) and multiple system atrophy (MSA). Recently, filamentous aggregations of phosphorylated \u03b1\u2010synuclein have been reported in the cytoplasm of Schwann cells, but not in axons, in the peripheral nervous system in MSA, mainly in the cranial and spinal nerve roots. Here we conducted an immunohistochemical investigation of the cranial and spinal nerves and dorsal root ganglia of patients with LBD. Lewy axons were found in the oculomotor, trigeminal and glossopharyngeal\u2010vagus nerves, but not in the hypoglossal nerve. The glossopharyngeal\u2010vagus nerves were most frequently affected, with involvement in all of 20 subjects. In the spinal nerve roots, Lewy axons were found in all of the cases examined. Lewy axons in the anterior nerves were more frequent and numerous in the thoracic and sacral segments than in the cervical and lumbar segments. On the other hand, axonal lesions in the posterior spinal nerve roots appeared to increase along a cervical\u2010to\u2010sacral gradient. Although Schwann cell cytoplasmic inclusions were found in the spinal nerves, they were only minimal. In the dorsal root ganglia, axonal lesions were seldom evident. These findings indicate that \u03b1\u2010synuclein pathology in the peripheral nerves is axonal\u2010predominant in LBD, whereas it is restricted to glial cells in MSA.<\/jats:p>","DOI":"10.1111\/neup.12269","type":"journal-article","created":{"date-parts":[[2015,11,13]],"date-time":"2015-11-13T09:19:56Z","timestamp":1447406396000},"page":"262-269","source":"Crossref","is-referenced-by-count":22,"title":["\u03b1\u2010Synuclein pathology in the cranial and spinal nerves in Lewy body disease"],"prefix":"10.1111","volume":"36","author":[{"given":"Keiko","family":"Nakamura","sequence":"first","affiliation":[{"name":"Department of Neuropathology, Institute of Brain Science Hirosaki University Graduate School of Medicine  Hirosaki"},{"name":"Department of Neurology and Neurobiology of Aging Kanazawa University Graduate School of Medical Science  Kanazawa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiaki","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, Institute of Brain Science Hirosaki University Graduate School of Medicine  Hirosaki"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunikazu","family":"Tanji","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, Institute of Brain Science Hirosaki University Graduate School of Medicine  Hirosaki"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Miki","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, Institute of Brain Science Hirosaki University Graduate School of Medicine  Hirosaki"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuko","family":"Toyoshima","sequence":"additional","affiliation":[{"name":"Department of Pathology, Brain Research Institute University of Niigata  Niigata"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiyoshi","family":"Kakita","sequence":"additional","affiliation":[{"name":"Department of Pathological Neuroscience, Center for Bioresource\u2010based Researches, Brain Research Institute University of Niigata  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Brain Research Institute University of Niigata  Niigata"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahito","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurobiology of Aging Kanazawa University Graduate School of Medical Science  Kanazawa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Wakabayashi","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, Institute of Brain Science Hirosaki University Graduate School of Medicine  Hirosaki"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(92)90923-U"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/62.6.644"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-010-0706-x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb748"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-010-0676-z"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(98)00890-8"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00007400"},{"key":"e_1_2_6_9_1","first-page":"163","article-title":"Aggregation of \u03b1\u2010synuclein\/NACP in the neuronal and glial cells in diffuse Lewy body disease: a survey of six patients","volume":"19","author":"Piao YS","year":"2000","journal-title":"Clin Neuropathol"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2990.2001.00345.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s00401-002-0622-9","article-title":"Glial involvement in diffuse Lewy body disease","volume":"105","author":"Terada S","year":"2003","journal-title":"Acta Neuropathol"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-007-0244-3"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(89)90219-0"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199009000-00007"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-003-0811-1"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-005-1013-9"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/61.5.413"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(02)00065-9"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21065"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-007-0316-4"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-007-0193-x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-012-1028-y"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-015-0208-0"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000187889.17253.b1"},{"key":"e_1_2_6_25_1","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1523\/JNEUROSCI.14-03-01820.1994","article-title":"Identification and characterization of a novel (115\u2009kDa) neurofilament\u2010associated kinase","volume":"14","author":"Xiao J","year":"1994","journal-title":"J Neurosci"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(82)90871-X"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2008.00140.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12168"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-010-0664-3"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004010050705"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00294619"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1159\/000113469"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000204179.88955.fa"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.2006.00727.x"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-009-0629-6"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.2011.01211.x"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-015-0236-9"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn102"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/167038"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2012.11.009"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2013.08.022"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.26.5.423"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2006.05.020"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2005.079053"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2008.2"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22142"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2013.09.016"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.23.4.283"}],"container-title":["Neuropathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fneup.12269","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/neup.12269","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T17:15:41Z","timestamp":1696180541000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/neup.12269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,13]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1111\/neup.12269"],"URL":"https:\/\/doi.org\/10.1111\/neup.12269","archive":["Portico"],"relation":{},"ISSN":["0919-6544","1440-1789"],"issn-type":[{"value":"0919-6544","type":"print"},{"value":"1440-1789","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,13]]}}}