{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T07:21:02Z","timestamp":1696576862718},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T00:00:00Z","timestamp":1456876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:p>The underlying pathological process of \u201cischemic leukoencephalopathy\u201d is not well studied in humans and \u201cdemyelination\u201d is thought to represent a major component. We selected brains from autopsy cases with definite histories of recent cardiac arrest, in which the autopsy findings demonstrated gray matter ischemic changes consistent with the survival time. We excluded cases with clinical or pathological evidence of other diseases that may affect the white matter, specifically those with moderate\u2010severe edema. The selected cases were then subjected to a review of the gross pathology (photographs) and microscopy. We used the normal white matter areas in the same brains as internal controls to exclude artefactual changes. Sixteen cases were selected. The pathological changes in acute ischemic leukoencephalopathy include: white matter pallor with separation of myelinated fibers and fine vacuoles, coarse vacuoles with or without attenuated axons, apoptotic nuclei, axonal abnormalities, focal scattered demyelinated axons and infarcts. The interpretation of these findings is controversial (i.e. ischemia, edema, artifact or combination) due to the postmortem nature of the specimens. However, these factors should not affect our interpretation of minimal demyelination in the pathological process. The major underlying pathological process in acute ischemic leukoencephalopathy is axonal degeneration, while demyelination represents only a minor component.<\/jats:p>","DOI":"10.1111\/neup.12287","type":"journal-article","created":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T07:52:59Z","timestamp":1456905179000},"page":"413-420","source":"Crossref","is-referenced-by-count":2,"title":["Acute hypoxic\u2010ischemia in cardiac arrest encephalopathy causes only minimal demyelination"],"prefix":"10.1111","volume":"36","author":[{"given":"Murad","family":"Alturkustani","sequence":"first","affiliation":[{"name":"Department of Pathology King Abdulaziz University  Jeddah Saudi Arabia"},{"name":"London Health Sciences Centre (LHSC)  London ON Canada"},{"name":"University of Western Ontario  London ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee\u2010Cyn","family":"Ang","sequence":"additional","affiliation":[{"name":"London Health Sciences Centre (LHSC)  London ON Canada"},{"name":"University of Western Ontario  London ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,2]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1513","volume-title":"Greenfield's neuropathology","author":"Raymond AS","year":"2008"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1976.00500010007002"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0000000000000008"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.27.4.761"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00809128"},{"key":"e_1_2_7_7_1","first-page":"327","article-title":"Histopathological changes in acute ischemic stroke","volume":"50","author":"Margaritescu O","year":"2009","journal-title":"Rom J Morphol Embryol"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.27.9.1641"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)90806-K"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199309000-00006"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0000000000000168"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-060909-153248"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199309000-00003"},{"issue":"2","key":"e_1_2_7_14_1","first-page":"259","article-title":"Perivascular demyelination and intramyelinic oedema in reperfusion nerve injury","volume":"185","author":"Nukada H","year":"1994","journal-title":"J Anat"}],"container-title":["Neuropathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fneup.12287","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/neup.12287","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T12:59:31Z","timestamp":1696510771000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/neup.12287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,2]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1111\/neup.12287"],"URL":"https:\/\/doi.org\/10.1111\/neup.12287","archive":["Portico"],"relation":{},"ISSN":["0919-6544","1440-1789"],"issn-type":[{"value":"0919-6544","type":"print"},{"value":"1440-1789","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,2]]}}}