{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T10:53:16Z","timestamp":1789901596903,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,3,11]],"date-time":"2016-03-11T00:00:00Z","timestamp":1457654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:p>Multiple system atrophy (MSA) is an adult\u2010onset neurodegenerative disease, which is characterized clinically by parkinsonism, cerebellar ataxia and\/or autonomic dysfunction, and pathologically by alpha\u2010synuclein\u2010related multisystem neurodegeneration, so\u2010called alpha\u2010synucleinopathy, which particularly involves the striatonigral and olivopontocerebellar systems, with glial cytoplasmic inclusions and neuronal cytoplasmic\/nuclear inclusions (NCIs\/NNIs). In the recent consensus criteria for the diagnosis of MSA, dementia is described as one of the features not supporting a diagnosis of MSA. However, MSA with dementia has been reported, although the location of the lesion responsible for the dementia remains unclear. In the present study, we aimed to investigate where this lesion may be found, by analyzing 12 autopsy\u2010proven MSA cases, with a particular focus on the medial temporal region. Three of 12 cases with MSA had dementia (MSA\u2010D). Compared with MSA cases without dementia, MSA\u2010D cases had frequent globular NCIs (G\u2010NCIs) in the medial temporal region, especially in their subiculum. In addition, MSA\u2010D cases could be divided into two types; MSA\u2010D with distinct fronto\u2010temporal lobar degeneration (FTLD type) and without distinct fronto\u2010temporal lobar degeneration (non\u2010FTLD type). There was no association between dementia and Alzheimer pathologies, such as neurofibrillary tangles and senile plaques. We suggest that frequent G\u2010NCIs in the medial temporal region, and particularly the subiculum, is one of the important pathological findings of MSA\u2010D, even when a case with MSA\u2010D reveals no significant cerebral atrophy.<\/jats:p>","DOI":"10.1111\/neup.12289","type":"journal-article","created":{"date-parts":[[2016,3,12]],"date-time":"2016-03-12T20:19:19Z","timestamp":1457813959000},"page":"421-431","source":"Crossref","is-referenced-by-count":38,"title":["Frequent globular neuronal cytoplasmic inclusions in the medial temporal region as a possible characteristic feature in multiple system atrophy with dementia"],"prefix":"10.1111","volume":"36","author":[{"given":"Taku","family":"Homma","sequence":"first","affiliation":[{"name":"Department of Pathology Tokyo Metropolitan Neurological Hospital  Fuchu Tokyo Japan"},{"name":"Department of Pathology Nihon University School of Medicine  Itabashi Tokyo 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