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In the present study, we evaluated the effects of an acute striatal lesion induced by a focal N\u2010methyl\u2010D\u2010aspartate (NMDA) microinjection on the morphometry of NADPH diaphorase\u2010reactive neurons (NADPH\u2010d<jats:sup>+<\/jats:sup>), a subset of cells which release nitric oxide (NO) in the brain and are known by its resistance in pathological conditions. Two hundred and forty NADPH\u2010d neurons from NMDA\u2010lesioned striatum and contralateral counterpart were tridimensionally reconstructed at 1, 3 and 7 post\u2010lesion days (PLDs). Cell body and dendritic field areas, length of dendrites by order and fractal dimension were analyzed. There were no significant morphometric differences when NADPH\u2010d<jats:sup>+<\/jats:sup> neurons from lesioned and control striatal regions were compared among PLDs evaluated. Conversely, a conspicuous pallor in striatal neuropil reactivity was evidenced, especially in latter survival time. In addition, we observed a noticeable inflammatory response induced by NMDA. Our results suggest that NADPH\u2010d<jats:sup>+<\/jats:sup> neurons were spared from deleterious effects of acute NMDA excitotoxic damage in the striatum, reinforcing the notion that this cell group is selectively resistant to injury in the nervous system.<\/jats:p>","DOI":"10.1111\/neup.12311","type":"journal-article","created":{"date-parts":[[2016,5,30]],"date-time":"2016-05-30T00:32:43Z","timestamp":1464568363000},"page":"527-534","source":"Crossref","is-referenced-by-count":16,"title":["Morphometric analysis of NADPH diaphorase reactive neurons in a rat model of focal excitotoxic striatal injury"],"prefix":"10.1111","volume":"36","author":[{"given":"Marco Aurelio M.","family":"Freire","sequence":"first","affiliation":[{"name":"Postgraduate Program in Health and Society Faculty of Health Sciences, State University of Rio Grande do Norte (UERN)  Mossor\u00f3 RN Brazil"},{"name":"Laboratory of Experimental Neuroprotection and Neuroregeneration Institute of Biological Sciences, 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