{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T15:36:38Z","timestamp":1764603398058},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T00:00:00Z","timestamp":1478476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:p>MV2\u2010type sporadic Creutzfeldt\u2010Jakob disease (sCJD), which was previously called \u201cKuru\u2010plaque variant\u201d, was gradually revealed to have a wide spectrum and has been classified into three pathological subtypes: MV2K, MV2C and MV2K\u00a0+\u00a0C. We herein describe the detailed clinical findings and neuropathologic observations from an autopsied MV2K\u00a0+\u00a0C\u2010type Japanese sCJD case with widespread cerebral cortical pathology and Kuru plaques. In the early stages of the disease, the patient exhibited gait disturbance with ataxia and dysarthria as well as gradual appearance of cognitive dysfunction. Diffusion\u2010weighted images (DWI) on MRI revealed extensive cerebral cortical hyperintensity. Pathologic investigation revealed extensive spongiform change in the cerebral cortex, particularly in the deeper layers. Vacuole size varied, and some were confluent. Prion protein (PrP) immunostaining revealed extensive PrP deposition in the cerebral cortex, basal ganglia, thalamus, cerebellum, brainstem and spinal cord. In the cerebral cortex, synaptic\u2010type, Kuru plaque\u2010like, and coarse plaque\u2010type PrP depositions were mainly observed, along with some perivacuolar\u2010type PrP depositions. Kuru plaques and coarse plaque\u2010type PrP depositions also were observed in the cerebellar cortex. PrP gene analysis revealed no mutations, and polymorphic codon 129 exhibited Met\/Val heterozygosity. Western blot analysis revealed a mixture of intermediate\u2010type PrP<jats:sup>Sc<\/jats:sup> and type 2 PrP<jats:sup>Sc<\/jats:sup>. Based on previous reports regarding MV2\u2010type sCJD and the clinicopathologic findings of the present case, we speculated that it may be possible to clinically distinguish each MV2 subtype. Clinical presentation of the MV2K\u00a0+\u00a0C subtype includes predominant cerebral cortical involvement signs with ataxia and DWI hyperintensity of the cerebral cortex on MRI.<\/jats:p>","DOI":"10.1111\/neup.12350","type":"journal-article","created":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T16:19:59Z","timestamp":1478535599000},"page":"241-248","source":"Crossref","is-referenced-by-count":6,"title":["An autopsied case of MV2K\u00a0+\u00a0C\u2010type sporadic Creutzfeldt\u2010Jakob disease presenting with widespread cerebral cortical involvement and Kuru plaques"],"prefix":"10.1111","volume":"37","author":[{"given":"Yasushi","family":"Iwasaki","sequence":"first","affiliation":[{"name":"Department of Neuropathology, Institute for Medical Science of Aging Aichi Medical University  Nagakute Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufuko","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Neurology National Hospital 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