{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T04:20:25Z","timestamp":1754194825762},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,1,2]],"date-time":"2017-01-02T00:00:00Z","timestamp":1483315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:p>In the surgical case of a mature cystic teratoma of the ovary that arose in a 16\u2010year\u2010old girl, a large amount of well\u2010differentiated and highly organized cerebellar tissue was found. Three layers of the cerebellar cortex were well formed, and synaptophysin\u2010positive \u201cglomeruli\u201d were found in the granule cell layer. Some Purkinje cells exhibited focal expansion and a dysmorphic appearance of the dendrites. Adjacent to the cerebellar tissue, a large space lined by the ependymal layer and a club\u2010shaped CNS tissue mass resembling the brainstem were found, and structures reminiscent of the midbrain tectum and pontine nuclei were distinguished within this mass. The CNS tissue was surrounded by the leptomeninges and a skull\u2010like, bony shell. Structures consistent with the supra\u2010tentorial CNS tissue were not found. This case represents an example of infra\u2010tentorial CNS tissue that was well\u2010differentiated and organized to an exceptionally high degree in an ovarian mature teratoma. Various degenerative changes have been documented in CNS tissue in ovarian teratomas, but the dendritic abnormalities of Purkinje cells seen in the present case are novel findings.<\/jats:p>","DOI":"10.1111\/neup.12360","type":"journal-article","created":{"date-parts":[[2017,1,2]],"date-time":"2017-01-02T06:02:40Z","timestamp":1483336960000},"page":"122-128","source":"Crossref","is-referenced-by-count":3,"title":["Well\u2010formed cerebellum and brainstem\u2010like structures in a mature ovarian teratoma: Neuropathological observations"],"prefix":"10.1111","volume":"37","author":[{"given":"Masayuki","family":"Shintaku","sequence":"first","affiliation":[{"name":"Department of Pathology Shiga Medical Center for Adults  Moriyama Shiga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiko","family":"Sakuma","sequence":"additional","affiliation":[{"name":"Department of Pathology Hyogo Cancer Center  Akashi Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiho","family":"Ohbayashi","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Nara Medical University  Kashihara Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoyoshi","family":"Maruo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hyogo Prefectural Kaibara Hospital  Tamba Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700400102"},{"key":"e_1_2_5_3_1","first-page":"1937","volume-title":"Pathology of the Nervous System","author":"Willis RA","year":"1971"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199308000-00002"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-199704000-00016"},{"key":"e_1_2_5_6_1","first-page":"187","article-title":"Glioblastoma multiforme in a dermoid cyst of the ovary. A case report","volume":"20","author":"Den Boon J","year":"1999","journal-title":"Eur J Gynaecol Oncol"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2004.01662.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000635"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21050"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.488"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197308)32:2<390::AID-CNCR2820320216>3.0.CO;2-W"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197501092920202"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700490312"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700530212"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700960235"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100020138"},{"key":"e_1_2_5_17_1","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1007\/BF00272501","article-title":"Structure of an isolated cerebellum and related nuclei developed within the matrix of a mature ovarian teratoma","volume":"2","author":"Ferrer I","year":"1986","journal-title":"Child's Nerv Syst"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(98)80062-9"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10024-004-7083-1"},{"key":"e_1_2_5_20_1","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.5858\/2006-130-1552-FTH","article-title":"Fetiform teratoma (homunculus)","volume":"130","author":"Weiss JR","year":"2006","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_5_21_1","first-page":"1255","article-title":"Well\u2010differentiated cerebellum within a mature cystic teratoma of the ovary","volume":"7","author":"Ishida M","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_5_22_1","first-page":"S98","article-title":"Cerebellar tissue components in ovarian teratoma","volume":"36","author":"Ujihira N","year":"2016","journal-title":"Neuropathology"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00691528"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1789.2003.00507.x"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01102115"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198105000-00007"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196801)21:1<38::AID-CNCR2820210108>3.0.CO;2-L"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1979.tb03000.x"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00686623"},{"key":"e_1_2_5_30_1","first-page":"88S","article-title":"Benign ovarian cystic teratomas with homunculi","volume":"61","author":"Weldon\u2010Linne CM","year":"1983","journal-title":"Obstet Gynecol"},{"key":"e_1_2_5_31_1","first-page":"1192","article-title":"Ovarian mature teratoma with homunculus coexisting with an intrauterine pregnancy","volume":"110","author":"Miyake J","year":"1986","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-198404000-00007"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181e24f06"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-195110010-00002"},{"key":"e_1_2_5_35_1","first-page":"533","article-title":"Heterotopic central nervous tissue in subarachnoid space","volume":"78","author":"Popoff N","year":"1964","journal-title":"Arch Pathol"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004010051089"},{"key":"e_1_2_5_37_1","first-page":"448","article-title":"Rosenthal fibers in ovarian teratomas","volume":"93","author":"Hardman JM","year":"1972","journal-title":"Arch Pathol"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.2005.00613.x"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00685385"},{"key":"e_1_2_5_40_1","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/BF00687433","article-title":"Paraneoplastic cortical cerebellar degeneration. A neuropathological study of an autopsy case in comparison with cortical cerebellar degeneration in alcoholics","volume":"77","author":"Mizutani T","year":"1988","journal-title":"Acta Neuropathol"}],"container-title":["Neuropathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fneup.12360","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/neup.12360","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T13:51:31Z","timestamp":1696168291000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/neup.12360"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,2]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1111\/neup.12360"],"URL":"https:\/\/doi.org\/10.1111\/neup.12360","archive":["Portico"],"relation":{},"ISSN":["0919-6544","1440-1789"],"issn-type":[{"value":"0919-6544","type":"print"},{"value":"1440-1789","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,2]]}}}