{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T07:41:57Z","timestamp":1696232517711},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T00:00:00Z","timestamp":1485820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:p>Dentatorubral\u2010pallidoluysian atrophy (DRPLA), one of the polyglutamine diseases, has not been reported in combination with ganglioglioma (GG). Herein, we report an autopsy case of a 72\u2010year\u2010old man with DRPLA with a small GG component harboring neurofibrillary tangles (NFTs) and polyglutamine aggregates. NFTs, cytoplasmic accumulations of hyper\u2010phosphorylated tau, are mainly observed in Alzheimer's disease (AD) and other tau\u2010associated neurodegenerative disorders. NFTs can also be present in normal aging, and are occasionally observed in low\u2010grade central nervous system (CNS) neoplasms such as GG. In the present case, whole brain examination demonstrated widespread deposition of polyglutamine aggregates, including GG, whereas NFTs were restricted to the GG component. In addition, no other AD or aging\u2010related neuropathological structures were detected throughout the CNS. These findings may provide us with clues to elucidate the pathogenetic mechanisms that neuronal neoplasms may have to develop NFTs regardless of aging, and that polyglutamine may accumulate in neoplastic neurons in polyglutamine disease.<\/jats:p>","DOI":"10.1111\/neup.12365","type":"journal-article","created":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T02:36:56Z","timestamp":1485916616000},"page":"335-340","source":"Crossref","is-referenced-by-count":4,"title":["Dentatorubral\u2010pallidoluysian atrophy (DRPLA) with a small ganglioglioma component containing neurofibrillary tangles and polyglutamine aggregation"],"prefix":"10.1111","volume":"37","author":[{"given":"Seiji","family":"Yamada","sequence":"first","affiliation":[{"name":"Department of Human Pathology Gunma University Graduate School of Medicine  Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Human Pathology Gunma University Graduate School of Medicine  Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Nakata","sequence":"additional","affiliation":[{"name":"Department of Human Pathology Gunma University Graduate School of Medicine  Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumihito","family":"Nobusawa","sequence":"additional","affiliation":[{"name":"Department of Human Pathology Gunma University Graduate School of Medicine  Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayato","family":"Ikota","sequence":"additional","affiliation":[{"name":"Department of Human Pathology Gunma University Graduate School of Medicine  Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Munenori","family":"Ide","sequence":"additional","affiliation":[{"name":"Department of Pathology Maebashi Red Cross Hospital  Maebashi Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuyuki","family":"Mizushima","sequence":"additional","affiliation":[{"name":"Department of Neurology Maebashi Red Cross Hospital  Maebashi Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuo","family":"Harigaya","sequence":"additional","affiliation":[{"name":"Department of Neurology Maebashi Red Cross Hospital  Maebashi Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko","family":"Hirato","sequence":"additional","affiliation":[{"name":"Department of Pathology Gunma University Hospital  Maebashi Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Yokoo","sequence":"additional","affiliation":[{"name":"Department of Human Pathology Gunma University Graduate School of Medicine  Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0194-9"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0194-14"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410370610"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.8.3.205"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.32.8.798"},{"key":"e_1_2_7_7_1","first-page":"1135","article-title":"Dentatorubral\u2010pallidoluysian atrophy (DRPLA): Its distribution in Japan and prevalence rate in Niigata","volume":"32","author":"Inazuki G","year":"1990","journal-title":"Seishin Igaku"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004010050933"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0298-111"},{"key":"e_1_2_7_10_1","volume-title":"WHO Classification of Tumours of the Central Nervous System, Revised","author":"IARC","year":"2016"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-013-1100-2"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-013-1195-5"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.11.4051"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.12.4506"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(84)80144-6"},{"key":"e_1_2_7_16_1","first-page":"1225","article-title":"Hypothalamic gangliocytoma. Selective appearance of neurofibrillary changes, granulovacuolar degeneration, and argentophilic bodies","volume":"36","author":"Kudo M","year":"1986","journal-title":"Acta Pathol Jpn"},{"key":"e_1_2_7_17_1","first-page":"653","article-title":"Ganglioglioma containing osseous tissue and neurofibrillary tangles","volume":"112","author":"Hori A","year":"1988","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00307651"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2990.2001.00311.x"},{"key":"e_1_2_7_20_1","first-page":"621","article-title":"Localization of S\u2010100 protein and glial fibrillary acidic protein\u2010related antigen in pleomorphic adenoma of the salivary glands","volume":"46","author":"Nakazato Y","year":"1982","journal-title":"Lab Invest"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-011-0802-6"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2014.94"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1993.79.6.0867"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00294510"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199507000-00005"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970301)79:5<989::AID-CNCR16>3.0.CO;2-Z"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/61.7.575"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2012.00582.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.49.6.1605"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10352"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12296"}],"container-title":["Neuropathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fneup.12365","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/neup.12365","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T20:31:48Z","timestamp":1696192308000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/neup.12365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,31]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/neup.12365"],"URL":"https:\/\/doi.org\/10.1111\/neup.12365","archive":["Portico"],"relation":{},"ISSN":["0919-6544","1440-1789"],"issn-type":[{"value":"0919-6544","type":"print"},{"value":"1440-1789","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,31]]}}}