{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T12:54:15Z","timestamp":1777294455114,"version":"3.51.4"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,3,13]],"date-time":"2017-03-13T00:00:00Z","timestamp":1489363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:p>We present a rare case of primary pituitary T cell lymphoma\/leukemia (T\u2010LBL) in association with adrenocorticotropic hormone (ACTH) and thyroid stimulating hormone (TSH) expressing pituitary adenoma in a 55\u2010year\u2010old woman highlighting the importance of intra\u2010operative squash smears examination. The patient presented with complaints of headache, diminution of vision and recent onset altered sensorium. MRI revealed a mass lesion in the sellar\u2010suprasellar region with non\u2010visualization of pituitary gland separately, extending to involve adjacent structures diagnosed as invasive pituitary macroadenoma. Intra\u2010operative tissue was sent for squash smear examination. The cytology showed a tumor comprising of sheets of immature lymphoid cells intermixed with clusters of pituitary acinar cells with many mitoses and tingible body macrophages. A diagnosis of presence of immature lymphoid cells within the pituitary was offered and differentials of infiltration by lymphoma cells from systemic disease versus primary central nervous lymphoma\u2010like lymphoma arising in the pituitary adenoma were considered. Later paraffin section examination and immunohistochemistry corroborated with the squash findings and a final diagnosis of primary pituitary T cell lymphoma\/leukemia in association with ACTH and TSH expressing pituitary adenoma was made. To date, only six cases of primary pituitary T cell lymphomas, including three T\u2010LBL cases, have been reported. This is the seventh case and first one additionally describing cytohistological correlation and importance of intra\u2010operative cytology.<\/jats:p>","DOI":"10.1111\/neup.12375","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T16:21:21Z","timestamp":1489508481000},"page":"358-364","source":"Crossref","is-referenced-by-count":14,"title":["T cell lymphoblastic lymphoma\/leukemia within an adrenocorticotropic hormone and thyroid stimulating hormone positive pituitary adenoma: A cytohistological correlation emphasizing importance of intra\u2010operative squash smear"],"prefix":"10.1111","volume":"37","author":[{"given":"Rakesh K.","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Pathology G B Pant Institute of Postgraduate Medical Education and Research  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9146-5783","authenticated-orcid":false,"given":"Ravindra K.","family":"Saran","sequence":"additional","affiliation":[{"name":"Department of Pathology G B Pant Institute of Postgraduate Medical Education and Research  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arvind K.","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery G B Pant Institute of Postgraduate Medical Education and Research  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Jagetia","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery G B Pant Institute of Postgraduate Medical Education and Research  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lalit","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis G B Pant Institute of Postgraduate Medical Education and Research  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehar C.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Pathology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,13]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"World Health Organization classification of tumours. 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Proceedings of the International Symposium on Neuroendocrine\u2010Oncology: Biological and Clinical Aspects. 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