{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T22:04:18Z","timestamp":1766268258292,"version":"3.37.3"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T00:00:00Z","timestamp":1489968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:p>Intravascular T\u2010cell lymphomas are rare, poorly characterized lesions. We discuss the clinical, radiologic and especially the laboratory characteristics of a lesion which presented in a 62\u2010year\u2010old woman with a history of progressive CNS abnormalities. Throughout the course of the disease, radiologic findings consisted mainly of multifocal mixed areas of ischemia and vasogenic edema involving cortical and subcortical regions. A brain biopsy identified an abnormal T\u2010cell population confined to lumens of vessels. These T\u2010cells were abnormal cytotoxic cells, positive for CD3, CD8, and negative for CD2, CD4, CD5, CD7 and CD30. While flow cytometry and immunohistochemistry failed to identify a similar population in the blood or bone marrow, molecular studies showed a clonal T\u2010cell population in both the brain and the bone marrow. No other organs were involved. In spite of aggressive treatment, the patient's medical condition continued to progress and she passed away. In conclusion, this abnormal population of cytotoxic T\u2010cells with intravascular localization probably represents a specific type of T\u2010cell lymphoma with specific clinical, radiologic, molecular and immunophenotypic characteristics.<\/jats:p>","DOI":"10.1111\/neup.12376","type":"journal-article","created":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T06:22:45Z","timestamp":1489990965000},"page":"365-370","source":"Crossref","is-referenced-by-count":13,"title":["Intravascular T\u2010cell lymphoma: A rare, poorly characterized entity with cytotoxic phenotype"],"prefix":"10.1111","volume":"37","author":[{"given":"Tara L.","family":"Sharma","sequence":"first","affiliation":[{"name":"Neurology Institute Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabrielle A.","family":"Yeaney","sequence":"additional","affiliation":[{"name":"Pathology Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Payam","family":"Soltanzadeh","sequence":"additional","affiliation":[{"name":"Neurology Institute Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuebing","family":"Li","sequence":"additional","affiliation":[{"name":"Neurology Institute Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0413-2014","authenticated-orcid":false,"given":"Claudiu V.","family":"Cotta","sequence":"additional","affiliation":[{"name":"Laboratory Medicine Departments Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,20]]},"reference":[{"volume-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","year":"2008","author":"Swerdlow SH","key":"e_1_2_7_2_1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-643569"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11107"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1309\/X597G3QMXAFBCM5V"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.9259"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2008.01089.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000000267"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.3984"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-005-0080-6"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2009.02376.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPXOE61CJDOAJI"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000217"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e31824fec43"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403202"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31815d29c9"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP1JLYXLGDNOCH"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.59.3.439"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.11-5-496"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-003-1961-1"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-015-0336-7"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-015-0330-0"}],"container-title":["Neuropathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fneup.12376","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/neup.12376","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T20:32:13Z","timestamp":1696192333000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/neup.12376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,20]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/neup.12376"],"URL":"https:\/\/doi.org\/10.1111\/neup.12376","archive":["Portico"],"relation":{},"ISSN":["0919-6544","1440-1789"],"issn-type":[{"type":"print","value":"0919-6544"},{"type":"electronic","value":"1440-1789"}],"subject":[],"published":{"date-parts":[[2017,3,20]]}}}