{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T10:27:30Z","timestamp":1779877650794,"version":"3.53.1"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,4,16]],"date-time":"2017-04-16T00:00:00Z","timestamp":1492300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:p>We report the case of a 79\u2010year\u2010old Japanese woman who developed cerebellar ataxia followed by rigidity, dysautonomia and cognitive disorders, and was thus clinically diagnosed as having possible MSA with dementia. Neuropathological findings demonstrated not only olivopontocerebellar and striatonigral degeneration with frequent glial cytoplasmic inclusions (GCIs), but also degenerative changes in the parahippocampal region, accentuated in the anterior portion of perirhinal cortex, where neuronal cytoplasmic inclusions (NCIs) and NFTs were numerous while GCIs were limited. NCIs were frequent in the deep layer, whereas NFTs were more frequent in superficial cortical layers. Other hippocampal subregions including subiculum, dentate fascia and cornu ammonis were minimally involved. NCIs in the perirhinal cortex showed intense argyrophilia with the Campbell\u2010Switzer silver impregnation method, but not argyrophilic with the Gallyas method. Most neuronal alpha\u2010synuclein aggregates in dendrosomatic fraction formed globular\/tadpole\u2010like, and ultrastructurally comprised granular\u2010coated fine fibrils 12\u201324\u00a0nm in diameter. To the best of our knowledge, alpha\u2010synuclein\u2010related neuronal pathology localized in the perirhinal region without hippocampal involvement has not been previously reported in MSA, and may provide clues to elucidate how neuronal pathology evolves in the hippocampal\/parahippocampal regions in MSA, particularly in cases with dementia.<\/jats:p>","DOI":"10.1111\/neup.12381","type":"journal-article","created":{"date-parts":[[2017,4,17]],"date-time":"2017-04-17T02:06:46Z","timestamp":1492394806000},"page":"431-440","source":"Crossref","is-referenced-by-count":12,"title":["Perirhinal accumulation of neuronal alpha\u2010synuclein in a multiple system atrophy patient with dementia"],"prefix":"10.1111","volume":"37","author":[{"given":"Mari","family":"Saito","sequence":"first","affiliation":[{"name":"Division of Neurology, Department of Medicine Nihon University School of Medicine  Tokyo 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