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Herein we describe the first autopsy case of histiocytic sarcoma presenting as a diffuse leptomeningeal disease in absence of a CNS tumor\u2010forming parenchymal lesion. The clinical, pathological and immunophenotypic features are described and an updated literature review on primary CNS histiocytic sarcoma is included.<\/jats:p>","DOI":"10.1111\/neup.12390","type":"journal-article","created":{"date-parts":[[2017,5,26]],"date-time":"2017-05-26T06:06:46Z","timestamp":1495778806000},"page":"517-525","source":"Crossref","is-referenced-by-count":25,"title":["Primary histiocytic sarcoma presenting as diffuse leptomeningeal disease: Case description and review of the literature"],"prefix":"10.1111","volume":"37","author":[{"given":"Magda","family":"Zanelli","sequence":"first","affiliation":[{"name":"Pathology Unit, Arcispedale Santa Maria Nuova \u2013 IRCCS Reggio Emilia  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moira","family":"Ragazzi","sequence":"additional","affiliation":[{"name":"Pathology Unit, Arcispedale Santa Maria Nuova \u2013 IRCCS Reggio Emilia  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Marchetti","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Ospedale di Terni University of Perugia  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8484-7871","authenticated-orcid":false,"given":"Alessandra","family":"Bisagni","sequence":"additional","affiliation":[{"name":"Pathology Unit, Arcispedale Santa Maria Nuova \u2013 IRCCS Reggio Emilia  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Principi","sequence":"additional","affiliation":[{"name":"Radiology Department, Ospedale di Terni University of Perugia  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Fanni","sequence":"additional","affiliation":[{"name":"Pathology Unit, Ospedale S. 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