{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T07:30:20Z","timestamp":1789889420559,"version":"4.0.1"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,7,9]],"date-time":"2017-07-09T00:00:00Z","timestamp":1499558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["16dm0107109h0001"],"award-info":[{"award-number":["16dm0107109h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["16kk0205009h0001"],"award-info":[{"award-number":["16kk0205009h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It is very rare that cases of Pick's disease, a representative three\u2010repeat (3R) tauopathy, also have significant four\u2010repeat (4R) tau accumulation. Here, we report a Pick's disease case that clinically showed behavioral variant frontotemporal dementia without motor disturbance during the course, and pathologically had 3R tau\u2010positive Pick bodies as well as numerous 4R tau\u2010positive neuronal cytoplasmic inclusions (NCIs). Abundant 3R tau\u2010positive 4R tau\u2010negative spherical or horseshoe\u2010shaped Pick bodies were found in the frontotemporal cortex, limbic region, striatum and pontine nucleus. On the other hand, many 4R tau\u2010positive, 3R tau\u2010negative, Gallyas\u2010negative dot\u2010, rod\u2010 or intertwined skein\u2010like NCIs were found mainly in the subthalamic nucleus, pontine nucleus, inferior olivary nucleus and cerebellar dentate nucleus. Tufted astrocytes, astrocytic plaques, argyrophilic grains or globular glial inclusions were absent. Double\u2010labeling immunofluorescence demonstrated that 3R tau was hardly accumulated in 4R tau\u2010positive inclusions. On tau immunoblotting, while 60 and 64\u00a0kDa bands were demonstrated in the frontal cortex, 60, 64 and 68\u00a0kDa bands, as well as the 33\u00a0kDa tau fragments that are reported to be characteristic of progressive supranuclear palsy brains, were found in the basal ganglia and cerebellum. No mutation was identified in the tau gene. The present case suggests that, although probably rare, some Pick's disease cases have non\u2010negligible 4R tau pathology in the subcortical nuclei, and that such 4R tau pathology can affect the evaluation of the distribution of AT8\u2010positive tau pathology in Pick's disease cases.<\/jats:p>","DOI":"10.1111\/neup.12394","type":"journal-article","created":{"date-parts":[[2017,7,10]],"date-time":"2017-07-10T03:44:33Z","timestamp":1499658273000},"page":"544-559","source":"Crossref","is-referenced-by-count":8,"title":["Pick's disease with neuronal four\u2010repeat tau accumulation in the basal ganglia, brain stem nuclei and cerebellum"],"prefix":"10.1111","volume":"37","author":[{"given":"Chikako","family":"Ikeda","sequence":"first","affiliation":[{"name":"Department of Neuropsychiatry Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences  Okayama 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