{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T21:08:23Z","timestamp":1773695303728,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,8,15]],"date-time":"2017-08-15T00:00:00Z","timestamp":1502755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:p>Herein, we present a rare case of gliosarcoma arising from oligodendroglioma, isocitrate dehydrogenase (<jats:italic>IDH<\/jats:italic>) mutant and 1p\/19q codeleted. A 36\u2010year\u2010old man presented with a non\u2010enhanced calcified abnormal lesion on the right frontal lobe. The patient underwent subtotal surgical resection, <jats:styled-content style=\"fixed-case\">PAV<\/jats:styled-content> chemotherapy (procarbazine, nimustine (ACNU) and vincristine), and fractionated radiotherapy with 50\u2009Gy. The pathological diagnosis was oligodendroglioma, <jats:italic>IDH<\/jats:italic> mutant and 1p\/19q codeleted, <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>orld <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ealth <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>rganization 2016 grade <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>. Six years later, a new enhanced lesion appeared, and the recurrent tumor was surgically removed. Although the histopathological findings indicated gliosarcoma, the recurrent tumor still demonstrated the <jats:italic>IDH<\/jats:italic> mutation and 1p\/19q codeleted. Thus, the recurrent tumor was considered to originate from oligodendroglioma, rather than being newly generated after chemoradiotherapy. Interestingly, the second recurrent tumor responded well to temozolomide chemotherapy. Based on the findings of this case, oligodendrogliomas have the potential for mesenchymal transformation on progression, while keeping their genotype.<\/jats:p>","DOI":"10.1111\/neup.12406","type":"journal-article","created":{"date-parts":[[2017,8,16]],"date-time":"2017-08-16T02:38:49Z","timestamp":1502851129000},"page":"41-46","source":"Crossref","is-referenced-by-count":6,"title":["Gliosarcoma arising from oligodendroglioma, <i>IDH<\/i> mutant and 1p\/19q codeleted"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2504-6385","authenticated-orcid":false,"given":"Takayuki","family":"Yasuda","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Nitta","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Tokyo Women's Medical University  Tokyo Japan"},{"name":"Faculty of Advanced Techno\u2010Surgery, Institute of Biomedical Engineering and Science Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6812-2149","authenticated-orcid":false,"given":"Takashi","family":"Komori","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology (Neuropathology) Tokyo Metropolitan Neurological Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenta","family":"Masui","sequence":"additional","affiliation":[{"name":"Department of Pathology Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Tokyo Women's Medical University  Tokyo Japan"},{"name":"Faculty of Advanced Techno\u2010Surgery, Institute of Biomedical Engineering and Science Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuo","family":"Sawada","sequence":"additional","affiliation":[{"name":"Department of Pathology Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Muragaki","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Tokyo Women's Medical University  Tokyo Japan"},{"name":"Faculty of Advanced Techno\u2010Surgery, Institute of Biomedical Engineering and Science Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takakazu","family":"Kawamata","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1212\/WNL.51.4.1140","article-title":"Response rate and prognostic factors of recurrent oligodendroglioma treated with procarbazine, CCNU, and vincristine chemotherapy. 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