{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:23:51Z","timestamp":1740126231869,"version":"3.37.3"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,8,18]],"date-time":"2017-08-18T00:00:00Z","timestamp":1503014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:p>Only two prior cases of benign dendritic melanocytes colonizing a meningioma have been reported. We add a third case, describe clinicopathologic features shared by the three, and elucidate the risk factors for this very rare phenomenon. A 29\u2009year\u2010old <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ispanic woman presented with headache and hydrocephalus. <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> showed a lobulated enhancing pineal region mass measuring 41\u2009mm in greatest dimension. Subtotal resection of the mass demonstrated an atypical meningioma, <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content> grade <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>, and the patient subsequently underwent radiotherapy. She presented 4\u2009years later with diplopia, and <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> showed an enhancing extra\u2010axial mass measuring 47\u2009mm in greatest dimension and centered on the tentorial incisura. Subtotal resection showed a brain\u2010invasive atypical meningioma with melanocytic colonization. The previous two cases in the literature were atypical meningiomas, one of which was also brain invasive. Atypical meningiomas may be at particular risk for melanocytic colonization as they upregulate molecules known to be chemoattractants for melanocytes. We detected c\u2010<jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>it expression in a minority of the melanocytes as well as stem cell factor and basic fibroblast growth factor in the meningioma cells, suggesting that mechanisms implicated in normal melanocyte migration may be involved. In some cases, brain invasion with disruption of the leptomeningeal barrier may also facilitate migration from the subarachnoid space into the tumor. Whether there is low\u2010level proliferation of the dendritic melanocytes is unclear. Given that all three patients were non\u2010<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>aucasian, meningiomas in persons and\/or brain regions with increased dendritic melanocytes may predispose to colonization. The age range spanned from 6\u2009years old to 70\u2009years old. All three patients were female. The role of gender and estrogen in the pathogenesis of this entity remains to be clarified. Whether melanocytic colonization may also occur in the more common <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>rade <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content> meningiomas awaits identification of additional cases.<\/jats:p>","DOI":"10.1111\/neup.12409","type":"journal-article","created":{"date-parts":[[2017,8,18]],"date-time":"2017-08-18T06:18:40Z","timestamp":1503037120000},"page":"54-61","source":"Crossref","is-referenced-by-count":2,"title":["Clinicopathologic features and pathogenesis of melanocytic colonization in atypical meningioma"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7611-1653","authenticated-orcid":false,"given":"Mitra","family":"Dehghan Harati","sequence":"first","affiliation":[{"name":"Division of Neuropathology, Department of Pathology and Laboratory Medicine David Geffen School of Medicine at UCLA University of California  Los Angeles California 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