{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T20:51:05Z","timestamp":1757451065337,"version":"3.37.3"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,10,3]],"date-time":"2017-10-03T00:00:00Z","timestamp":1506988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:p>Medulloepithelioma is a rare and highly malignant primitive neuroectodermal tumor that usually occurs in childhood. The diagnosis of this entity required only morphological analysis until the World Health Organization classification of central nervous system (CNS) tumors was revised, and now genetic analysis is necessary. We report a case of medulloepithelioma in the posterior cranial fossa that was diagnosed by both morphological and genetic analyses based on this classification. A 10\u2010month\u2010old girl was admitted to our hospital with consciousness disturbance and vomiting. Neuroimaging revealed a partially calcified mass and cyst formation in the posterior cranial fossa. Partial resection of the tumor was performed and histological findings revealed multilayered rosettes with LIN28A staining, but genetic analysis showed no amplification of the <jats:italic>C19MC<\/jats:italic> microRNA cluster at 19q14.32. Therefore, we diagnosed the tumor as medulloepithelioma belonging to other CNS embryonal tumors. The patient was immediately treated with systemic high\u2010dose chemotherapy. Follow\u2010up neuroimaging 10\u2009months later showed no signs of recurrence. Medulloepitheliomas are difficult to diagnose by routine HE staining and require combined morphological, immunohistochemical and genetic analyses to provide an accurate diagnosis.<\/jats:p>","DOI":"10.1111\/neup.12431","type":"journal-article","created":{"date-parts":[[2017,10,3]],"date-time":"2017-10-03T07:16:45Z","timestamp":1507015005000},"page":"179-184","source":"Crossref","is-referenced-by-count":9,"title":["Combined morphological, immunohistochemical and genetic analyses of medulloepithelioma in the posterior cranial fossa"],"prefix":"10.1111","volume":"38","author":[{"given":"Kosuke","family":"Kusakabe","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Ehime University School of Medicine  Toon Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shohei","family":"Kohno","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Ehime University School of Medicine  Toon 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of Neurosurgery Ehime University School of Medicine  Toon Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Iwata","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Ehime Prefectural Central Hospital  Matsuyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko","family":"Hirato","sequence":"additional","affiliation":[{"name":"Department of Pathology Gunma University Hospital  Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeharu","family":"Kunieda","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Ehime University School of Medicine  Toon Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,3]]},"reference":[{"volume-title":"A Classification of Tumors of the Glioma Group on a Histogenetic Basis with a Correlated Study of Progress","year":"1926","author":"Baily 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