{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T12:14:14Z","timestamp":1777032854197,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T00:00:00Z","timestamp":1510012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>Catatonia is a clinical syndrome characterized by symptoms such as immobility, mutism, stupor, stereotypy, echophenomena, catalepsy, automatic obedience, posturing, negativism, gegenhalten and ambitendency. This syndrome occurs mostly in mood disorder and schizophrenic patients, and is related to neuronal dysfunction involving the frontal lobe. Some cases of frontotemporal dementia (FTD) with catatonia have been reported, but these cases were not examined by autopsy. Here, we report on a FTD case which showed catatonia after the first episode of brief psychotic disorder. At the age of 58, the patient had a sudden onset of disorganized behavior and meaningless speech. Psychotropic drugs were effective for catatonic symptoms. However, after remission apathy, hyperorality, socially inappropriate behavior, hoarding, and an instinctive grasp reaction appeared and persisted. Brain MRI showed significant atrophy of the bilateral fronto\u2010temporal lobes. A neuropathological examination revealed extensive trans\u2010activation response DNA\u2010binding protein 43 (TDP\u201043) positive neurocytoplasmic inclusions and dystrophic neurites in the brain, including the cerebral cortex, basal ganglia, and brainstem. Pathological diagnosis was frontotemporal lobar degeneration (FTLD) with TDP\u201043 (FTLD\u2010TDP) type C, which was also confirmed by the band pattern of C\u2010terminal fragments of TDP\u201043 on western blotting of sarkosyl\u2010insoluble fractions extracted from the frozen brain. Dysfunction of the thalamus, globus pallidus, supplementary motor area, amygdala and cingulate cortex have been said to be related to the catatonic syndrome. In this case, these areas were affected, showing abnormal TDP\u201043\u2010positive structures. Further studies are expected to confirm further clinical \u2010 pathological correlations to FTLD.<\/jats:p>","DOI":"10.1111\/neup.12442","type":"journal-article","created":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T05:38:36Z","timestamp":1510033116000},"page":"281-287","source":"Crossref","is-referenced-by-count":10,"title":["Frontotemporal dementia with trans\u2010activation response DNA\u2010binding protein 43 presenting with catatonic syndrome"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0775-656X","authenticated-orcid":false,"given":"Ryohei","family":"Watanabe","sequence":"first","affiliation":[{"name":"Dementia Reserch Project Tokyo Metropolitan Institute of Medical Science  Tokyo Japan"},{"name":"Department of Psychiatry University of Tsukuba  Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ito","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Dementia Reserch Project Tokyo Metropolitan Institute of Medical Science  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsumoto","family":"Onaya","sequence":"additional","affiliation":[{"name":"Department of Pschiatry National Hospital Organization Shimofusa Psychiatric Medical Center  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Higashi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Tsukuba  Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobutaka","family":"Arai","sequence":"additional","affiliation":[{"name":"Laboratory of Neuropathology Tokyo Metropolitan Institute of Medical Science  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruhiko","family":"Akiyama","sequence":"additional","affiliation":[{"name":"Dementia Reserch Project Tokyo Metropolitan Institute of Medical Science  Tokyo 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