{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T21:22:24Z","timestamp":1778534544050,"version":"3.51.4"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T00:00:00Z","timestamp":1513555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["28\u20104"],"award-info":[{"award-number":["28\u20104"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["29\u20106"],"award-info":[{"award-number":["29\u20106"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>A rosette\u2010forming glioneuronal tumor (RGNT) was initially reported as an infratentorial tumor that comprised both small neurocytic rosettes and astrocytic components. However, a few studies have reported supratentorial RGNTs arising in the cerebral hemispheres. Here, we report an unusual case involving a 9\u2010year\u2010old boy with a supratentorial RGNT who presented with intractable epilepsy and behavioral changes. Brain MRI revealed a well\u2010circumscribed space\u2010occupying lesion with septae in the right inferomedial parietal lobe. Electroencephalography showed multifocal spikes over the right frontal, temporal and parietal regions. The seizure frequency decreased dramatically after tumorectomy. Histopathological examination revealed prominent neurocytic rosette formation appearing with the specific glioneuronal element of a dysembryoplastic neuroepithelial tumor (DNT). Although the pathogenesis has not been elucidated, a supratentorial RGNT presenting with epilepsy may exhibit a rosette component, which is the major feature of this tumor, against the background of a specific glioneuronal element mimicking DNT. However, RGNT arising in regions other than the fourth ventricle is rare, and the pathogenesis of epilepsy due to RGNT has not been fully elucidated. Further clinical and histological studies are required to understand the pathology underlying epilepsy caused by RGNT.<\/jats:p>","DOI":"10.1111\/neup.12450","type":"journal-article","created":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T08:48:02Z","timestamp":1513586882000},"page":"300-304","source":"Crossref","is-referenced-by-count":10,"title":["Intractable epilepsy due to a rosette\u2010forming glioneuronal tumor with a dysembryoplastic neuroepithelial background"],"prefix":"10.1111","volume":"38","author":[{"given":"Noriko","family":"Sumitomo","sequence":"first","affiliation":[{"name":"Department of Child Neurology National Center Hospital, National Center of Neurology and Psychiatry (NCNP)  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9203-1581","authenticated-orcid":false,"given":"Akihiko","family":"Ishiyama","sequence":"additional","affiliation":[{"name":"Department of Child Neurology National Center Hospital, National Center of Neurology and Psychiatry (NCNP)  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Shibuya","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine National Center Hospital, NCNP  Tokyo Japan"},{"name":"Central Laboratory Hachioji Medical Center, Tokyo Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiji","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Child Neurology National Center Hospital, National Center of Neurology and Psychiatry (NCNP)  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery National Center Hospital, NCNP  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akio","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery National Center Hospital, NCNP  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taisuke","family":"Otsuki","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery National Center Hospital, NCNP  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiyoshi","family":"Kakita","sequence":"additional","affiliation":[{"name":"Department of Pathology Brain Research Institute, Niigata University  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine National Center Hospital, NCNP  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Radiology National Center Hospital, NCNP  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Sugai","sequence":"additional","affiliation":[{"name":"Department of Child Neurology National Center Hospital, National Center of Neurology and Psychiatry (NCNP)  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Child Neurology National Center Hospital, National Center of Neurology and Psychiatry (NCNP)  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200205000-00004"},{"key":"e_1_2_8_3_1","first-page":"150","volume-title":"WHO Classification of Tumors of the Central Nervous System","author":"Hainfellner 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