{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T04:40:54Z","timestamp":1780461654008,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T00:00:00Z","timestamp":1520294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:p>Globular glial tauopathy (GGT) is a 4\u2010repeat (4R) tauopathy in which 4R tau accumulates to form globular glial inclusions (GGIs), predominantly in oligodendroglia. To date, little has been reported on iron deposits in patients with GGT. We report a case of GGT with iron deposits in a 78\u2010year\u2010old woman presenting with an 8\u2010year history of slowly progressing limb weakness and cognitive decline. Susceptibility\u2010weighted imaging revealed a low signal intensity in the right precentral gyrus, suggesting iron deposition. A clinical diagnosis of motor neuron disease with dementia was made 4\u2009years after onset. At autopsy, gross pathological findings showed atrophy of the frontal and temporal lobes. A localized area of the precentral gyrus corresponding to the most severely affected limb showed the strongest atrophy, macroscopically, and displayed 4R tau\u2010immunoreactive GGIs and microscopically many ferritin\u2010immunoreactive neurons. We diagnosed this patient as having GGT. This is the first GGT case with iron deposition confirmed both radiologically and pathologically.<\/jats:p>","DOI":"10.1111\/neup.12457","type":"journal-article","created":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T08:18:50Z","timestamp":1520324330000},"page":"372-379","source":"Crossref","is-referenced-by-count":16,"title":["An autopsy case of globular glial tauopathy presenting with clinical features of motor neuron disease with dementia and iron deposition in the motor cortex"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1403-3797","authenticated-orcid":false,"given":"Itsuki","family":"Hasegawa","sequence":"first","affiliation":[{"name":"Department of Neurology Osaka City University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akitoshi","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Neurology Osaka City University Graduate School of Medicine  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