{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T09:08:25Z","timestamp":1759741705771,"version":"3.37.3"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T00:00:00Z","timestamp":1520208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:p>A 51\u2010year\u2010old man presented with a 2\u2010week history of malaise. MRI revealed a large solid and cystic lesion with ring enhancement measuring 6.5\u2009cm in diameter in the right frontal lobe. Histologically, the tumor consisted of various components: diffuse growth of atypical astrocytic cells consistent with glioblastoma, fascicular proliferation of atypical spindle cells such as fibrosarcoma, clusters of primitive neuronal cells, and foci of ependymal cells. The sarcomatous component also focally exhibited chondroid and osteoid differentiation. Immunohistochemically, tumor cells in the primitive neuronal component were immunoreactive for synaptophysin and CD56. The spindle cells were immunopositive for Slug and Twist, regulators of epithelial\u2010mesenchymal transition. Direct DNA sequencing demonstrated C228T mutation in the <jats:italic>TERT<\/jats:italic> promoter in astrocytic, sarcomatous and primitive neuronal components, suggesting their identical origin. Although a few cases of gliosarcoma with primitive neuronal differentiation have previously been described, the finding that neuronal, glial and sarcomatous components share an identical mutation of the <jats:italic>TERT<\/jats:italic> promoter has not been reported. The tumor recurred at the original site 11\u2009months after the first surgery. Interestingly, the recurrent tumor was composed exclusively of a glioblastomatous component, unlike past cases of recurrent gliosarcoma.<\/jats:p>","DOI":"10.1111\/neup.12461","type":"journal-article","created":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T07:28:39Z","timestamp":1520234919000},"page":"392-399","source":"Crossref","is-referenced-by-count":4,"title":["Gliosarcoma with primitive neuronal, chondroid, osteoid and ependymal elements"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5799-913X","authenticated-orcid":false,"given":"Yuka","family":"Yoshida","sequence":"first","affiliation":[{"name":"Department of Human Pathology Gunma University Graduate School of Medicine  Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Munenori","family":"Ide","sequence":"additional","affiliation":[{"name":"Department of Pathology Maebashi Red Cross Hospital  Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroya","family":"Fujimaki","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Maebashi Red Cross Hospital  Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6592-6582","authenticated-orcid":false,"given":"Nozomi","family":"Matsumura","sequence":"additional","affiliation":[{"name":"Department of Human Pathology Gunma University Graduate School of Medicine  Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumihito","family":"Nobusawa","sequence":"additional","affiliation":[{"name":"Department of Human Pathology Gunma University Graduate School of Medicine  Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayato","family":"Ikota","sequence":"additional","affiliation":[{"name":"Department of Human Pathology Gunma University Graduate School of Medicine  Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Yokoo","sequence":"additional","affiliation":[{"name":"Department of Human Pathology Gunma University Graduate School of Medicine  Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,5]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"48","volume-title":"World Health Organization Classification of Tumors of the Central Nervous System","author":"Burger PC","year":"2016"},{"doi-asserted-by":"publisher","key":"e_1_2_6_3_1","DOI":"10.1097\/00005072-199509000-00006"},{"doi-asserted-by":"publisher","key":"e_1_2_6_4_1","DOI":"10.1097\/00005072-199609000-00004"},{"doi-asserted-by":"publisher","key":"e_1_2_6_5_1","DOI":"10.1016\/S0002-9440(10)64746-3"},{"doi-asserted-by":"publisher","key":"e_1_2_6_6_1","DOI":"10.1111\/bpa.12328"},{"doi-asserted-by":"publisher","key":"e_1_2_6_7_1","DOI":"10.1007\/s004010050554"},{"key":"e_1_2_6_8_1","first-page":"219","article-title":"A lateral ventricular gliosarcoma arising in an ependymoma","volume":"20","author":"Higashino T","year":"2001","journal-title":"Clin Neuropathol"},{"doi-asserted-by":"publisher","key":"e_1_2_6_9_1","DOI":"10.1016\/j.humpath.2003.10.018"},{"doi-asserted-by":"publisher","key":"e_1_2_6_10_1","DOI":"10.1097\/PAS.0b013e318158234e"},{"doi-asserted-by":"publisher","key":"e_1_2_6_11_1","DOI":"10.1002\/1097-0142(19890201)63:3<518::AID-CNCR2820630320>3.0.CO;2-5"},{"doi-asserted-by":"publisher","key":"e_1_2_6_12_1","DOI":"10.1007\/s00701-009-0341-2"},{"doi-asserted-by":"publisher","key":"e_1_2_6_13_1","DOI":"10.1002\/1097-0142(19930801)72:3<850::AID-CNCR2820720334>3.0.CO;2-4"},{"doi-asserted-by":"publisher","key":"e_1_2_6_14_1","DOI":"10.4103\/0377-4929.77324"},{"doi-asserted-by":"publisher","key":"e_1_2_6_15_1","DOI":"10.1111\/j.1440-1827.2008.02242.x"},{"key":"e_1_2_6_16_1","first-page":"212","article-title":"Gliosarcoma with areas of primitive neuroepithelial differentiation and extracranial metastasis","volume":"20","author":"Wharton SB","year":"2001","journal-title":"Clin Neuropathol"},{"key":"e_1_2_6_17_1","first-page":"218","article-title":"Mixed cystic gliosarcoma and primitive neuroectodermal tumor: A case report","volume":"23","author":"Dulai MS","year":"2004","journal-title":"Clin Neuropathol"},{"doi-asserted-by":"publisher","key":"e_1_2_6_18_1","DOI":"10.1007\/s11060-007-9331-5"},{"doi-asserted-by":"publisher","key":"e_1_2_6_19_1","DOI":"10.1002\/dc.21133"},{"doi-asserted-by":"publisher","key":"e_1_2_6_20_1","DOI":"10.1111\/j.1750-3639.2008.00167.x"},{"doi-asserted-by":"publisher","key":"e_1_2_6_21_1","DOI":"10.1111\/neup.12318"},{"doi-asserted-by":"publisher","key":"e_1_2_6_22_1","DOI":"10.5414\/NP300624"},{"key":"e_1_2_6_23_1","first-page":"2079","article-title":"Gliosarcoma with primitive neuronal, osseous, cartilage and adipocyte differentiation: A case report","volume":"8","author":"Yao K","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"doi-asserted-by":"publisher","key":"e_1_2_6_24_1","DOI":"10.1111\/j.1750-3639.2012.00571.x"},{"doi-asserted-by":"publisher","key":"e_1_2_6_25_1","DOI":"10.4103\/0976-3147.91944"},{"doi-asserted-by":"publisher","key":"e_1_2_6_26_1","DOI":"10.1007\/s11060-005-4174-4"}],"container-title":["Neuropathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fneup.12461","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/neup.12461","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T12:59:08Z","timestamp":1694955548000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/neup.12461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,5]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1111\/neup.12461"],"URL":"https:\/\/doi.org\/10.1111\/neup.12461","archive":["Portico"],"relation":{},"ISSN":["0919-6544","1440-1789"],"issn-type":[{"type":"print","value":"0919-6544"},{"type":"electronic","value":"1440-1789"}],"subject":[],"published":{"date-parts":[[2018,3,5]]}}}