{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T20:33:43Z","timestamp":1783110823885,"version":"3.54.6"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T00:00:00Z","timestamp":1525219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:p>Peripheral neuropathy occurs in approximately 5% of the patients with lymphoma. Two major causes of peripheral neuropathy associated with lymphoma are neurolymphomatosis and paraneoplastic neuropathy such as demyelinating neuropathy. The differential diagnosis between neurolymphomatosis and demyelinating neuropathy is difficult, because electrophysiological findings suggestive of demyelination are frequently observed even in patients with neurolymphomatosis. Here, we report a patient with de novo CD5\u2010positive diffuse large B\u2010cell lymphoma (DLBCL) who presented with Guillain\u2013Barr\u00e9 syndrome (GBS)\u2010like neuropathy. Demyelination due to paraneoplastic neuropathy was clinically suspected. However, autopsy demonstrated that the cause of the neuropathy was neurolymphomatosis. Clinical courses of neurolymphomatosis vary and neurolymphomatosis cases presenting with GBS\u2010like neuropathy are reported. In addition, DLBCL is the most frequent histological type of malignant lymphoma that develops neurolymphomatosis. Furthermore, \u201cCD5\u2010positive\u201d DLBCL may tend to develop neurolymphomatosis. If a patient with \u201cCD5\u2010positive\u201d DLBCL develops peripheral neuropathy, neurolymphomatosis should be considered and imaging studies performed and, if possible, nerve tissue biopsy, regardless of clinical symptoms of the neuropathy. To our knowledge, this is the first report of a patient with de novo CD5\u2010positive DLBCL with neurolymphomatosis who presented with GBS\u2010like neuropathy.<\/jats:p>","DOI":"10.1111\/neup.12470","type":"journal-article","created":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T15:52:24Z","timestamp":1525276344000},"page":"417-421","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["First pathological report of a de novo CD5\u2010positive diffuse large B\u2010cell lymphoma patient presenting with Guillain\u2013Barr\u00e9 syndrome\u2010like neuropathy due to neurolymphomatosis"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2757-6117","authenticated-orcid":false,"given":"Mikiko","family":"Kobayashi","sequence":"first","affiliation":[{"name":"Department of Pathology Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathology Shinshu University Graduate School of Medicine  Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Kariya","sequence":"additional","affiliation":[{"name":"Department of Pathology Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Sakai","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiyo","family":"Hineno","sequence":"additional","affiliation":[{"name":"Department of Medicine (Neurology and Rheumatology) Shinshu University School of Medicine  Matsumoto Japan"},{"name":"Intractable Disease Care Center Shinshu University Hospital  Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyomitsu","family":"Oyanagi","sequence":"additional","affiliation":[{"name":"Division of Neuropathology, Department of Brain Disease Research Shinshu University School of Medicine  Matsumoto Japan"},{"name":"Brain Research Laboratory Hatsuishi Hospital  Kashiwa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Kanno","sequence":"additional","affiliation":[{"name":"Department of Pathology Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1177\/014107689408700915","article-title":"Effects of lymphoma on the peripheral nervous system","volume":"87","author":"Hughes RA","year":"1994","journal-title":"J R Soc Med"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt193"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/118.5.1233"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/apm.12123"},{"key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1007\/s00428-003-0809-z","article-title":"Mantle cell lymphoma: Improved diagnostics using a combined approach of immunohistochemistry and identification of t(11;14)(q13;q32) by polymerase chain reaction and fluorescence in situ hybridization","volume":"442","author":"Kodet R","year":"2003","journal-title":"Virchows Arch"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26090"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.1182\/blood.V128.22.3042.3042","article-title":"Clinical features, diagnosis, and prognosis of 14 cases of neurolymphomatosis: Single institutional experience over 10 years","volume":"128","author":"Abe Y","year":"2016","journal-title":"Blood"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.12810"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.05177.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-01-021253"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-016-8190-4"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.2.243"},{"key":"e_1_2_10_14_1","doi-asserted-by":"crossref","first-page":"645","DOI":"10.5858\/2000-124-0646-PQCPDW","article-title":"Pathologic quiz case: Progressive diffuse weakness after chemotherapy for large cell lymphoma in a middle\u2010aged woman. Lymphomatous meningitis with neurolymphomatosis","volume":"124","author":"Carey MJ","year":"2000","journal-title":"Arch Pathol Lab Med"}],"container-title":["Neuropathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fneup.12470","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/neup.12470","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T12:59:23Z","timestamp":1694955563000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/neup.12470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,2]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1111\/neup.12470"],"URL":"https:\/\/doi.org\/10.1111\/neup.12470","archive":["Portico"],"relation":{},"ISSN":["0919-6544","1440-1789"],"issn-type":[{"value":"0919-6544","type":"print"},{"value":"1440-1789","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,2]]},"assertion":[{"value":"2017-12-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}