{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:39:36Z","timestamp":1790710776748,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,7,26]],"date-time":"2018-07-26T00:00:00Z","timestamp":1532563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:p>Low\u2010grade neuroepithelial tumors (LGNT) show a broad histopathological spectrum and may be difficult to classify using current World Health Organization (WHO) criteria. A 57\u2010year\u2010old man came to medical attention because of headaches. The patient medical history was otherwise unremarkable. Magnetic resonance imaging (MRI) revealed a 2.5 cm lesion, partially cystic, with an increased signal on T2\u2010weighted imaging, located in the right frontal lobe. The patient underwent right frontal craniotomy and the surgical specimen was entirely evaluated. Microscopic examination showed a tumor arranged predominantly in sheets and nests, with an infiltrative growth pattern and oligodendroglioma\u2010like appearance. Tumor cells were round to oval with cytoplasmic clearing, hyperchromatic nuclei and inconspicuous nucleoli. Only one mitosis was identified. Necrosis was absent. Differential diagnostic considerations included oligodendroglioma, clear cell ependymoma, polymorphous low\u2010grade neuroepithelial tumor of the young (PLNTY) and long\u2010term epilepsy\u2010associated tumor with clear cell morphology. Neoplastic cells showed positivity for glial fibrillary acidic protein (GFAP), oligodendrocyte transcription factor 2 (OLIG2), \u03b1\u2010thalasemia X\u2010linked mental retardation syndrome (ATRX) (retained nuclear expression) and CD34. Epithelial membrane antigen (EMA), neuronal nuclear antigen, microtubule\u2010associated protein\u20102e, cyclo\u2010oxygenase\u20102, chromogranin A and isocitrate dehydrogenase 1 (IDH1) (R132H) were negative. Ki\u201067 labeling index was 2\u20133%. Molecular analysis identified neither IDH1\/IDH2 mutations nor 1p19q codeletion. Rapidly accelerated fibrosarcoma homolog B1 (BRAF) V600E mutation was also absent by both molecular and immunohistochemical testing. Polymerase chain reaction analysis revealed the presence of <jats:italic>fibroblast growth factor receptor 3 (FGFR3)\u2010transforming acidic coiled\u2010coil (TACC)<\/jats:italic> fusion. Taken together, the morphological, immunohistochemical and molecular findings supported the final diagnosis of PLNTY.<\/jats:p>","DOI":"10.1111\/neup.12504","type":"journal-article","created":{"date-parts":[[2018,7,27]],"date-time":"2018-07-27T03:50:08Z","timestamp":1532663408000},"page":"557-560","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Low\u2010grade neuroepithelial tumor: Unusual presentation in an adult without history of seizures"],"prefix":"10.1111","volume":"38","author":[{"given":"Giulio","family":"Riva","sequence":"first","affiliation":[{"name":"Pathology Unit, Department of Diagnostics and Public Health University and Hospital Trust of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3180-5843","authenticated-orcid":false,"given":"Luca","family":"Cima","sequence":"additional","affiliation":[{"name":"Pathology Unit, Department of Diagnostics and Public Health University and Hospital Trust of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Villanova","sequence":"additional","affiliation":[{"name":"Pathology Unit, Department of Diagnostics and Public Health University and Hospital Trust of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Ghimenton","sequence":"additional","affiliation":[{"name":"Pathology Unit, Department of Diagnostics and Public Health University and Hospital Trust of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sokol","family":"Sina","sequence":"additional","affiliation":[{"name":"Pathology Unit, Department of Diagnostics and Public Health University and Hospital Trust of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Riccioni","sequence":"additional","affiliation":[{"name":"Pathology Unit M. Bufalini Hospital  Cesena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giada","family":"Munari","sequence":"additional","affiliation":[{"name":"Surgical Pathology Unit, Department of Medicine (DIMED) University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Fassan","sequence":"additional","affiliation":[{"name":"Surgical Pathology Unit, Department of Medicine (DIMED) University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felice","family":"Giangaspero","sequence":"additional","affiliation":[{"name":"Department of Radiological, Oncological and Anatomo\u2010Pathological Sciences Sapienza University  Rome Italy"},{"name":"IRCCS Neuromed  Pozzilli Molise Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albino","family":"Eccher","sequence":"additional","affiliation":[{"name":"Pathology Unit, Department of Diagnostics and Public Health University and Hospital Trust of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-014-1288-9"},{"key":"e_1_2_7_3_1","volume-title":"WHO Classification of Tumours of the Central Nervous System","author":"Louis DN","year":"2016"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1639-9"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1545-1"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073815579709"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20332"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e3182302475"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12081"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2011.03936.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2400854"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10014-015-0236-2"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.2010.01188.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.2006.00734.x"}],"container-title":["Neuropathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fneup.12504","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/neup.12504","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T06:56:36Z","timestamp":1694933796000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/neup.12504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,26]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1111\/neup.12504"],"URL":"https:\/\/doi.org\/10.1111\/neup.12504","archive":["Portico"],"relation":{},"ISSN":["0919-6544","1440-1789"],"issn-type":[{"value":"0919-6544","type":"print"},{"value":"1440-1789","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,26]]},"assertion":[{"value":"2018-04-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}