{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T07:48:42Z","timestamp":1759564122043,"version":"3.37.3"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,8,19]],"date-time":"2018-08-19T00:00:00Z","timestamp":1534636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:p>Proteinase K\u2010resistant prion protein (PrP<jats:sup>Res<\/jats:sup>) nuclear and perinuclear immunoreactivity in oligodendrocytes of the frontal cortex is found in one case of otherwise typical sporadic Creutzfeldt\u2010Jakob disease (sCJD) type VV2a. The PrP nature of the inclusions is validated with several anti\u2010PrP antibodies directed to amino acids 130\u2013160 (12F10), 109\u2013112 (3F4), 97\u2013102 (8G8) and the octarepeat region (amino acids 59\u201389: SAF32). Cellular identification and subcellular localization were evaluated with double\u2010 and triple\u2010labeling immunofluorescence and confocal microscopy using antibodies against PrP, glial markers, and histone H3. Based on review of the literature and our own experience, this is a very odd situation that deserves further validation in other cases.<\/jats:p>","DOI":"10.1111\/neup.12505","type":"journal-article","created":{"date-parts":[[2018,8,20]],"date-time":"2018-08-20T02:25:41Z","timestamp":1534731941000},"page":"561-567","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Sporadic Creutzfeldt\u2013Jakob disease with glial PrP<sup>Res<\/sup> nuclear and perinuclear immunoreactivity"],"prefix":"10.1111","volume":"38","author":[{"given":"Ivan","family":"Fern\u00e1ndez\u2010Vega","sequence":"first","affiliation":[{"name":"Pathology Department Hospital Universitario Araba  Vitoria Spain"},{"name":"Brain Bank Hospital Universitario Araba, Biobanco Vasco para la Investigaci\u00f3n (O+eHun)  Vitoria 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