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Head computed tomography revealed severe hippocampal atrophy, whereas the atrophy of the frontal lobe was considerably mild for her age. Behavioral and psychological symptoms of dementia were relatively inconspicuous during the disease course. Apolipoprotein E gene analysis showed <jats:italic>\u03b53\/\u03b54<\/jats:italic> heterozygosity. She died at the age of 100 years and she was clinically diagnosed as having Alzheimer's disease (AD). Autopsy revealed numerous neurofibrillary tangles, particularly in the hippocampal region, and extensively distributed senile plaques in the brain. Although the findings were compatible with the pathological criteria for AD, combined pathologies of hippocampal sclerosis, trans\u2010activation response DNA\u2010binding protein 43 kDa, and \u03b1\u2010synuclein were also revealed. We believe that the clinicopathological findings of the present case are of significance for the diagnosis of elderly dementia and pathogenesis of AD.<\/jats:p>","DOI":"10.1111\/neup.12521","type":"journal-article","created":{"date-parts":[[2018,11,9]],"date-time":"2018-11-09T09:49:28Z","timestamp":1541756968000},"page":"653-659","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Autopsied centenarian case of Alzheimer's disease combined with hippocampal sclerosis, TDP\u201043, and \u03b1\u2010synuclein pathologies"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0059-3104","authenticated-orcid":false,"given":"Yasushi","family":"Iwasaki","sequence":"first","affiliation":[{"name":"Department of Neuropathology, Institute for Medical Science of Aging Aichi Medical University  Nagakute 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