{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:48:03Z","timestamp":1747187283625,"version":"3.40.5"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T00:00:00Z","timestamp":1557187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15K08369"],"award-info":[{"award-number":["15K08369"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:p>We encountered an autopsy case of sporadic Creutzfeldt\u2010Jakob disease (CJD) pathologically classified as MM1+2C\u2010type, where Western blot analysis of prion protein (PrP) mainly showed type\u20101 scrapie PrP (PrP<jats:sup>Sc<\/jats:sup>) but also, partially, mixed type\u20102 PrP<jats:sup>Sc<\/jats:sup>. A Japanese woman complained of visual disorder at the age of 86\u2009years and then showed disorientation and memory disturbances. Magnetic resonance imaging (MRI) showed cerebral cortical hyperintensity on diffusion\u2010weighted images. The patient died 2\u2009months after the onset of symptoms; her condition did not reach the akinetic mutism state and periodic sharp\u2010wave complexes on electroencephalography and myoclonus were not recognized. The brain weighed 1100\u2009g and neuropathological examination showed extensive fine vacuole\u2010type spongiform changes in the cerebral cortex. In some cortical regions, large confluent vacuole\u2010type spongiform changes were also present. Gliosis and hypertrophic astrocytosis were generally mild, and tissue rarefaction of the neuropil and neuronal loss were not apparent. PrP immunostaining showed diffuse synaptic\u2010type PrP deposition in the cerebral gray matter, but some regions with large confluent vacuoles showed perivacuolar\u2010type deposition. We speculated, based on the clinicopathological findings and previous reports, that most MM1\u2010type sporadic CJD cases may be associated with type\u20102 PrP<jats:sup>Sc<\/jats:sup>, at least partially, within certain regions of the cerebrum.<\/jats:p>","DOI":"10.1111\/neup.12557","type":"journal-article","created":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T07:42:18Z","timestamp":1557214938000},"page":"240-247","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Autopsied case of sporadic Creutzfeldt\u2013Jakob disease classified as MM1+2C\u2010type"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0059-3104","authenticated-orcid":false,"given":"Yasushi","family":"Iwasaki","sequence":"first","affiliation":[{"name":"Department of Neuropathology Institute for Medical Science of Aging, Aichi Medical University  Nagakute 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