{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T11:27:50Z","timestamp":1747913270791,"version":"3.40.5"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T00:00:00Z","timestamp":1574380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:p>Granulomatous amoebic encephalitis caused by free\u2010living amoebae is a rare condition that is difficult to diagnose and hard to treat, generally being fatal. Anti\u2010amoebic treatment is often delayed because clinical signs and symptoms may hide the probable causing agent misleading the appropriate diagnostic test. There are four genera of free\u2010living amoeba associated with human infection, <jats:italic>Naegleria<\/jats:italic>, <jats:italic>Acanthamoeba<\/jats:italic> sp., <jats:italic>Balamuthia<\/jats:italic> and <jats:italic>Sappinia<\/jats:italic>. Two boys were admitted with diagnosis of acute encephalitis. The history of having been in contact with swimming pools and rivers, supports the suspicion of an infection due to free\u2010living amoebae. In both cases a brain biopsy was done, the histology confirmed granulomatous amoebic encephalitis with the presence of amoebic trophozoites.<\/jats:p>","DOI":"10.1111\/neup.12617","type":"journal-article","created":{"date-parts":[[2019,11,23]],"date-time":"2019-11-23T05:28:44Z","timestamp":1574486924000},"page":"180-184","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Fatal granulomatous amoebic encephalitis due to free\u2010living amoebae in two boys in two different hospitals in Lima, Per\u00fa"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2284-6042","authenticated-orcid":false,"given":"Alfonso Mart\u00edn","family":"Cabello\u2010V\u00edlchez","sequence":"first","affiliation":[{"name":"Laboratory of Protozoa and Pathogenic Endosymbionts Instituto de Medicina Tropical \u201cAlexander von Humboldt\u201d, Universidad Peruana Cayetano Heredia  Lima Per\u00fa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel A.","family":"Chura\u2010Araujo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Hospital Nacional Alberto Sabogal  Lima Per\u00fa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4225-8953","authenticated-orcid":false,"given":"William E.","family":"Anicama Lima","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Nacional Guillermo Almenara  Lima Per\u00fa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9sar","family":"Vela","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Nacional Alberto Sabogal  Lima Per\u00fa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4708-8372","authenticated-orcid":false,"given":"Ang\u00e9lica Y.","family":"Asencio","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Nacional Guillermo Almenara  Lima Per\u00fa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Nacional Alberto Sabogal  Lima Per\u00fa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"del Carmen Garaycochea","sequence":"additional","affiliation":[{"name":"Department of Virology National Institute of Health (NIH)  Lima Per\u00fa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9sar","family":"N\u00e1quira","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Tropical Daniel A. 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