{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T00:52:56Z","timestamp":1781398376173,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T00:00:00Z","timestamp":1579478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:p>We investigated the distribution and formation of new lymphatic vessels in gliomas. Specimens from seven glioma cases were analyzed by immunohistochemical staining for CD34, lymphatic endothelial hyaluronic acid receptor 1 (LYVE\u20101), prospero\u2010related homeobox 1 (Prox1), nestin, and hypoxia\u2010inducible factor 1\u03b1 (HIF\u20101\u03b1). Three types of vessels were observed in glioma specimens: LYVE\u20101<jats:sup>+<\/jats:sup> lymphatic vessels, CD34<jats:sup>+<\/jats:sup> blood vessels, and LYVE\u20101<jats:sup>+<\/jats:sup>\/CD34<jats:sup>+<\/jats:sup> blood vessels. Prox1<jats:sup>+<\/jats:sup>\/LYVE\u20101<jats:sup>+<\/jats:sup> cells were distributed in some lymphatic vessels as well as among vascular endothelial cells and glioma cells. Nestin<jats:sup>+<\/jats:sup> cells were scattered throughout the gliomas, and some lymphatic cells also expressed nestin. HIF\u20101\u03b1<jats:sup>+<\/jats:sup> Prox1<jats:sup>+<\/jats:sup> cells were widely distributed within the glioma specimens. The present immunohistochemical analysis revealed upregulation of Prox1 and HIF\u20101\u03b1 in some glioma tissues as well as the differentiation of nestin<jats:sup>+<\/jats:sup> tumor stem cells into LYVE\u20101<jats:sup>+<\/jats:sup> lymphatic vessels.<\/jats:p>","DOI":"10.1111\/neup.12625","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T07:06:11Z","timestamp":1579590371000},"page":"215-223","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Formation of new lymphatic vessels in glioma: An immunohistochemical analysis"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2068-2275","authenticated-orcid":false,"given":"Fan\u2010Wei","family":"Meng","sequence":"first","affiliation":[{"name":"Department of Anatomy and Physiology Shandong College of Traditional Chinese Medicine  Yantai 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