{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:45:31Z","timestamp":1747187131959,"version":"3.40.5"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T00:00:00Z","timestamp":1592352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:p>We examined 29 cases in which cerebral amyloid angiopathy (CAA) was detected among routine aged autopsies. Most cases with severe CAA had many amyloid\u2010\u03b2 (A\u03b2) plaques in the occipital cortex. Nonetheless, two cases had few A\u03b2 plaques with many small vessels and capillaries with CAA. In the two cases, severe CAA was widely distributed, except in the frontal lobes. A\u03b2 deposits in capillaries often showed the characteristic pattern of dysphoric amyloid angiopathy. A few naked plaques were present. Although A\u03b2 plaques were sparse near small vessels with CAA, there were many A\u03b2 plaques distant from small vessels with CAA. Some of the remaining plaques had a moth\u2010eaten appearance. Based on A\u03b2\u2010positive star\u2010like appearance and results of double immunohistochemistry for glial fibrillary acidic protein and A\u03b2<jats:sub>1\u201342<\/jats:sub>, some astrocytes appeared to contain A\u03b2. Ionized calcium\u2010binding adapter molecule 1 (Iba1)\u2010positive microglia were scattered within the neuropil, with some present around small vessels with CAA. Iba1\u2010positive microglia also seemed to phagocytose A\u03b2 in several senile plaques by double immunostaining. Neurons and neurites identified with a monoclonal antibody against phosphorylated tau (clone AT8) were occasionally detected in sparse plaque areas, with AT8\u2010identified dot\u2010like structures present around capillaries with CAA. Accumulation of T lymphocytes was detected around vessels in the subarachnoid space in one case. The morphological changes detected in our two cases were similar to those of morphological markers of plaque clearance after A\u03b2 immunotherapy. Nonetheless, our cases did not receive A\u03b2 immunotherapy, but similar pathologies were observed. Overall, advanced CAA cases, including our two cases, may be examples of plaque clearance without A\u03b2 immunotherapy. Further studies are needed to resolve the mechanism of A\u03b2 plaque clearance using these cases.<\/jats:p>","DOI":"10.1111\/neup.12662","type":"journal-article","created":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T01:29:45Z","timestamp":1592443785000},"page":"474-481","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Amyloid\u2010\u03b2 plaques may be reduced in advanced stages of cerebral amyloid angiopathy in the elderly"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4396-5040","authenticated-orcid":false,"given":"Koichi","family":"Okamoto","sequence":"first","affiliation":[{"name":"Department of Neurology Geriatrics Research Institute and Hospital  Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masakuni","family":"Amari","sequence":"additional","affiliation":[{"name":"Department of Neurology Geriatrics Research Institute and 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