{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:37:12Z","timestamp":1761824232673,"version":"3.40.5"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T00:00:00Z","timestamp":1597708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:p>High mobility group AT\u2010hook 2 (HMGA2) is a non\u2010histone transcriptional regulator protein. Aberrant expression of the HMGA2 gene (<jats:italic>HMGA2<\/jats:italic>) and structural rearrangement at the chromosomal region 12q14 with <jats:italic>HMGA2<\/jats:italic> involvement have been reported in several mesenchymal tumors. We analyzed truncated and full\u2010length <jats:italic>HMGA2<\/jats:italic> expression in 55 cases of meningioma, the most common brain tumor of mesenchymal origin. Fluorescence <jats:italic>in situ<\/jats:italic> hybridization and 3\u2032\u2010rapid amplification of cDNA ends were used to investigate the possibility of gene rearrangements. Moreover, the relationship between <jats:italic>HMGA2<\/jats:italic> expression and clinicopathological features was assessed. Compared with normal brain tissues, 95% of the meningioma tissues exhibited increased <jats:italic>HMGA2<\/jats:italic> expression. In 14 cases, the expression of truncated <jats:italic>HMGA2<\/jats:italic> was more than two\u2010fold higher than that of paired full\u2010length <jats:italic>HMGA2<\/jats:italic>. Chromosomal translocation involving the chromosomal region 12q14 was undetectable. No significant correlation was found between the Ki\u201067 labeling index and <jats:italic>HMGA2<\/jats:italic> expression and between the <jats:italic>HMGA2<\/jats:italic> expression and the clinicopathological features. The majority of the meningioma cases displayed increased <jats:italic>HMGA2<\/jats:italic> expression, which was not attributed to the chromosomal rearrangement at the corresponding region. Similar to that in the other mesenchymal tumors, increased <jats:italic>HMGA2<\/jats:italic> expression was not associated with tumor cell proliferation in meningiomas.<\/jats:p>","DOI":"10.1111\/neup.12670","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T04:41:49Z","timestamp":1598589709000},"page":"540-545","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["High <scp><i>HMGA2<\/i><\/scp> expression without gene rearrangement in meningiomas"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5729-2575","authenticated-orcid":false,"given":"Masaya","family":"Nagaishi","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Dokkyo Medical University Saitama Medical Center  Koshigaya\u2010shi, Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuta","family":"Nakae","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Dokkyo Medical University Saitama Medical Center  Koshigaya\u2010shi, Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Dokkyo Medical University Saitama Medical Center  Koshigaya\u2010shi, Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiko","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Dokkyo Medical University Saitama Medical Center  Koshigaya\u2010shi, Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Sugiura","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Dokkyo Medical University Saitama Medical Center  Koshigaya\u2010shi, Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoji","family":"Takigawa","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Dokkyo Medical University Saitama Medical Center  Koshigaya\u2010shi, Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kensuke","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Dokkyo Medical University Saitama Medical Center  Koshigaya\u2010shi, Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00125480-199909000-00001"},{"key":"e_1_2_7_3_1","first-page":"775","article-title":"HMGI\u2010C expression patterns in human tissues. 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