{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:14:54Z","timestamp":1790795694259,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T00:00:00Z","timestamp":1605657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:p>An autopsy case of acute actinomycotic brain abscess involving a patient with rheumatoid arthritis (RA) is reported. The patient was a 72\u2010year\u2010old man with a seven\u2010year history of RA and pulmonary complications, who acutely developed dysarthria and dysphagia three days before death. Autopsy revealed a fresh, non\u2010encapsulated abscess in the \u201clate cerebritis\u201d stage, measuring 2\u2009cm in diameter, in the white matter of the right parietal lobe. A small number of tiny \u201csulfur granules\u201d consisting of numerous filamentous bacilli were found within the abscess. The abscess had ruptured to the lateral ventricle and elicited ventriculitis, and mild acute purulent leptomeningitis was also observed. The lung showed chronic interstitial pneumonia\/pulmonary fibrosis with bronchiectasis and emphysema, and large sulfur granules were found in the lumens of a few bronchi. Less than 5% of patients with actinomycotic infection develop central nervous system lesions, and actinomycotic brain abscesses make up only 0.6% of all brain abscesses. Actinomycotic brain abscesses usually pursue a protracted clinical course, and well\u2010formed pyogenic membranes are commonly observed. The present case is exceptional in that the very early stage of the cerebral abscess formation was pathologically captured.<\/jats:p>","DOI":"10.1111\/neup.12699","type":"journal-article","created":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T01:32:07Z","timestamp":1605749527000},"page":"641-645","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Acute actinomycotic brain abscess in a patient with rheumatoid arthritis"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7162-9293","authenticated-orcid":false,"given":"Masayuki","family":"Shintaku","sequence":"first","affiliation":[{"name":"Department of Pathology Shiga General Hospital  Moriyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumihiko","family":"Kono","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Uji\u2010Tokushukai Medical Center  Uji Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Ando","sequence":"additional","affiliation":[{"name":"Department of Neurology Shiga General Hospital  Moriyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yugo","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Neurology Shiga General Hospital  Moriyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Neurology Shiga General Hospital  Moriyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4136-9678","authenticated-orcid":false,"given":"Yutaka","family":"Tsutsumi","sequence":"additional","affiliation":[{"name":"Pathos Tsutsumi  Toyoake Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1301635"},{"key":"e_1_2_6_3_1","first-page":"1192","volume-title":"Greenfield's Neuropathology","author":"Deckert M","year":"2015"},{"key":"e_1_2_6_4_1","first-page":"922","article-title":"Actinomycosis of the brain. 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