{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:37:23Z","timestamp":1761824243235,"version":"3.40.5"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,25]],"date-time":"2020-10-25T00:00:00Z","timestamp":1603584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:p>We describe a patient who had primary glioblastoma (GB) and malignant melanoma (MM). A 78\u2010year\u2010old man presented with several weeks to months of history of gait disturbance, confusion, memory disturbance, and worsening speech. Imaging studies performed on admission revealed a large frontotemporal lobe mass associated with the surrounding zone of vasogenic edema. Given the patient's medical history of incomplete biopsy of a midback tumor performed three weeks before, the presumptive clinical diagnosis was metastatic MM. Pathological examination of frozen sections of fragmented specimens obtained at stereotactic biopsy performed on admission revealed a high\u2010grade malignant neoplasm characterized by discohesive cells in a blue myxoid background and abundant foci of tumor necrosis. Given these features, in conjunction with the abovementioned pathological report, the frozen section diagnosis by the neuropathologist was \u201cneoplasm identified, favor melanoma.\u201d Due to the paucity of lesional tissue, a limited immunohistochemistry performed on the permanent sections revealed positive staining of lesional cells for Sox10 alone using a multiplex MART1\/Sox10 immunostain and S\u2010100 protein, an immunohistochemical profile supporting the presumptive frozen section diagnosis. A tumor debulk procedure, performed two\u2009weeks later, revealed histopathologic features most compatible with GB, IDH wild\u2010type. Thus, additional immunohistochemistry on the permanent sections revealed positive staining of glial fibrillary acidic protein (GFAP), Sox10, and S\u2010100 protein as well as negative staining of gp100, a complex carbohydrate matrix protein in embryonic melanosomes, using a specific antibody HMB45. The concomitant occurrence of MM and GB in our patient underscores the association between these two entities. Our literature review suggests that the sporadic co\u2010occurrence of these two conditions is likely not serendipitous.<\/jats:p>","DOI":"10.1111\/neup.12702","type":"journal-article","created":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T01:26:19Z","timestamp":1603675579000},"page":"65-71","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Glioblastoma and malignant melanoma: Serendipitous or anticipated association?"],"prefix":"10.1111","volume":"41","author":[{"given":"Kevin","family":"Yang","sequence":"first","affiliation":[{"name":"Tufts University School of Medicine  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thor D.","family":"Stein","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Boston University School of Medicine  Boston Massachusetts USA"},{"name":"VA Boston Healthcare System  Jamaica Plain Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertrand R.","family":"Huber","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Boston University School of Medicine  Boston Massachusetts USA"},{"name":"VA Boston Healthcare System  Jamaica Plain Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmett A.","family":"Sartor","sequence":"additional","affiliation":[{"name":"VA Boston Healthcare System  Jamaica Plain Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob R.","family":"Rachlin","sequence":"additional","affiliation":[{"name":"VA Boston Healthcare System  Jamaica Plain Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2800-9985","authenticated-orcid":false,"given":"Meera","family":"Mahalingam","sequence":"additional","affiliation":[{"name":"Tufts University School of Medicine  Boston Massachusetts USA"},{"name":"Dermatopathology Section Department of Pathology and Laboratory Medicine, VA Consolidated Laboratories  West Roxbury Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.05.125"},{"key":"e_1_2_7_3_1","unstructured":"American Cancer Society. Key statistics for melanoma skin cancer.2019[Cited Jan 2020.]. Available from URL:https:\/\/www.cancer.org\/cancer\/melanoma-skin-cancer\/about\/key-statistics.html."},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19951101)76:9<1571::AID-CNCR2820760912>3.0.CO;2-6"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(98)00341-4"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-013-1063-0"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.9.1728"},{"key":"e_1_2_7_8_1","first-page":"2298","article-title":"Germ\u2010line deletion involving the INK4 locus in familial proneness to melanoma and nervous system tumors","volume":"58","author":"Bahuau M","year":"1998","journal-title":"Cancer Res"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.5414\/NP301022"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2008.26.15_suppl.2082"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2014.02.010"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2007.00891.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00182084"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-07-0113"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-2797"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-2018"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12014"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-011-0802-6"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature00766"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e318279f3db"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1303607110"},{"key":"e_1_2_7_22_1","first-page":"1555","article-title":"Telomerase activity and hTERT mRNA expression in glial tumors","volume":"28","author":"Boldrini L","year":"2006","journal-title":"Int J Oncol"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1229259"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1230062"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-3272"},{"key":"e_1_2_7_26_1","first-page":"384","article-title":"Germline mutations in shelterin complex genes are associated with familial glioma","volume":"107","author":"Bainbridge MN","year":"2014","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2947"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2013.04.004"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2018.30.2.129"}],"container-title":["Neuropathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/neup.12702","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/neup.12702","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/neup.12702","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T12:07:42Z","timestamp":1693656462000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/neup.12702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,25]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1111\/neup.12702"],"URL":"https:\/\/doi.org\/10.1111\/neup.12702","archive":["Portico"],"relation":{},"ISSN":["0919-6544","1440-1789"],"issn-type":[{"type":"print","value":"0919-6544"},{"type":"electronic","value":"1440-1789"}],"subject":[],"published":{"date-parts":[[2020,10,25]]},"assertion":[{"value":"2020-05-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}