{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T21:20:07Z","timestamp":1757452807473,"version":"3.40.5"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T00:00:00Z","timestamp":1618185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:p>We report autopsy results of a female patient who was confirmed pathologically as having corticobasal degeneration (CBD). This patient presented with progressive gait disturbance at the age of 66\u2009years, and subsequently showed parkinsonism with a right\u2010sided predominance and dementia. She was clinically diagnosed as having possible corticobasal syndrome without palatal myoclonus throughout the disease course. An autopsy at 72\u2009years of age revealed that neuronal loss with gliosis was severe in the substantia nigra and the portion from hippocampal cornu ammonis (CA1) region to the parahippocampal gyrus, and mild\u2010to\u2010moderate in the basal ganglia, thalamus, red nucleus, dentate nucleus, and cerebral cortices, predominantly in the frontal lobe. Myelin pallor was observed in the pyramidal tract of the brainstem and central tegmental tract. Neurodegenerative or axonal degenerative findings were observed predominantly on the left side, except for the dentate nucleus, which was more affected on the right side. The inferior olivary nucleus exhibited hypertrophic degeneration predominantly on the left side. The topography of neurodegeneration was likely to correspond to the dentate nucleus and inferior olivary nucleus. Phosphorylated tau\u2010immunoreactive pretangles, neurofibrillary tangles, coiled bodies, and threads were diffusely observed in the whole brain. The distribution of tau deposits was prominent in the deeper affected lesions of the dentate nucleus and inferior olivary nucleus. Inferior olivary hypertrophy is unusual in patients with CBD. It is highly possible that the neurodegeneration of the inferior olivary nucleus followed that of the dentate nucleus in our patient. Moreover, these results indicate not only the severity of neurodegenerative changes, but also that of tau deposition that could be related to the topography of the projections of the dentato\u2010olivary pathway. Tau propagation and subsequent neurodegeneration along the fiber connections may have occurred. Our results support the possibility that progression of CBD lesions can be mediated by tau propagation.<\/jats:p>","DOI":"10.1111\/neup.12725","type":"journal-article","created":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T01:39:51Z","timestamp":1618277991000},"page":"226-235","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["An autopsy case of corticobasal degeneration with inferior olivary hypertrophy"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1948-5381","authenticated-orcid":false,"given":"Chiho","family":"Ishida","sequence":"first","affiliation":[{"name":"Department of Neurology National Hospital Organization Iou National Hospital, Hokuriku Brain and Neuromuscular Disease Center  Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Kato\u2010Motozaki","sequence":"additional","affiliation":[{"name":"Department of Neurology National Hospital Organization Iou National Hospital, Hokuriku Brain and Neuromuscular Disease Center  Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Noto","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurobiology of Aging Kanazawa University Graduate School of Medical Sciences  Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyonobu","family":"Komai","sequence":"additional","affiliation":[{"name":"Department of Neurology National Hospital Organization Iou National Hospital, Hokuriku Brain and Neuromuscular Disease Center  Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7415-8159","authenticated-orcid":false,"given":"Masato","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Dementia and Higher Brain Function Tokyo Metropolitan Institute of Medical Science  Tokyo 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