{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,8]],"date-time":"2025-06-08T21:23:42Z","timestamp":1749417822894,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T00:00:00Z","timestamp":1620172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:p>A case of olfactory neuroblastoma (ONB) associated with extensive intraepithelial neoplastic proliferation, evidenced by an \u201c<jats:italic>in situ<\/jats:italic>\u201d lesion, in the overlying olfactory epithelium and aberrant glandular and rhabdomyosarcomatous differentiation is reported. The tumor was a polypoid lesion that involved the upper nasal cavity and ethmoid sinus of a 63\u2010year\u2010old woman and consisted of an ONB surrounded by and mixed with a proliferative lesion of rhabdomyoblastic cells, consistent with an embryonal rhabdomyosarcoma. A few small foci of tubular glands with mucus\u2010producing cells were also observed. In the olfactory epithelium covering the polypoid lesion, a nested or band\u2010like arrangement of primitive\u2010appearing small cells was found, and the tumor cells were immunoreactive for epithelial cell adhesion molecule (detected with Ber\u2010EP4) and low\u2010molecular weight cytokeratin (detected with CAM5.2) but not for synaptophysin or calretinin. The intraepithelial lesion was contiguous with the subepithelial cell nests of ONB and appeared to invade the subjacent stroma and show transition to ONB, and some tumor cell nests of ONB also contained small aggregates of similar primitive\u2010appearing cells. The intraepithelial growth was considered to represent a preinvasive precursor lesion of ONB. Previous descriptions of an \u201c<jats:italic>in situ<\/jats:italic>\u201d lesion in ONB are limited. The aberrant glandular and rhabdomyosarcomatous differentiation noted in this case is also an exceptionally rare phenomenon of ONB.<\/jats:p>","DOI":"10.1111\/neup.12730","type":"journal-article","created":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T16:46:26Z","timestamp":1620319586000},"page":"273-280","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Olfactory neuroblastoma associated with extensive \u201c<i>in situ<\/i>\u201d lesion and aberrant glandular and rhabdomyosarcomatous differentiation"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7162-9293","authenticated-orcid":false,"given":"Masayuki","family":"Shintaku","sequence":"first","affiliation":[{"name":"Department of Pathology Hikone Municipal Hospital  Hikone Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Ohta","sequence":"additional","affiliation":[{"name":"Department of Pathology Hikone Municipal Hospital  Hikone Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Kataoka","sequence":"additional","affiliation":[{"name":"Department of Oto\u2010Rhino\u2010Laryngology Hikone Municipal Hospital  Hikone Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetoshi","family":"Okabe","sequence":"additional","affiliation":[{"name":"Department of Pathology Nishinotoin Bukkoji Clinic  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950701)76:1<4::AID-CNCR2820760103>3.0.CO;2-E"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-009-0125-2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0b013e3181b544cf"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.55418\/9781933477206","volume-title":"Tumors of the Upper Aerodigestive Tract and Ear. 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