{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T23:10:44Z","timestamp":1787094644746,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,9,19]],"date-time":"2021-09-19T00:00:00Z","timestamp":1632009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:p>Intravascular large B\u2010cell lymphoma (IVLBCL) is a rare form of lymphomas with poor prognosis, characterized by atypical lymphocytes selectively growing within the lumen of small or medium\u2010sized vessels. Here, we report a case of intracerebral IVLBCL in a 54\u2010year\u2010old man who died three months after symptom onset. The diagnosis was made by postmortem pathological examination, based on the identification of multiple ischemic lesions, with small or medium\u2010sized vessels filled with malignant B\u2010cells, in the cerebral hemispheres, cerebellum, midbrain, and medulla oblongata, including the external cuneate nucleus and trigeminal spinal tract nucleus. Apart from necrotic lesions, specific histopathological search for occluded vessels in the other brain stem structures permitted identification of significant involvement of the cuneate nucleus, solitary tract nucleus, hypoglossal nucleus, and inferior olivary complex. Small vessels affected by IVLBCL were also found in the trunks of the oculomotor, trigeminal, glossopharyngeal, vagal, and hypoglossal nerves. These histopathological findings were consistent with some cranial nerve symptoms\/signs ascertained during hospitalization, such as diplopia, dysphonia, and asymmetry\/hypomotility of the palatal veil. The case study presented here reports novel insights on radiological, anatomical, and clinical correlations of the IVLBCL, including the possible involvement of nuclei and trunks of multiple cranial nerves. The reported findings may help clinicians in the early identification of this rapidly progressive disease that can be easily misdiagnosed, through integrated neuroradiological, neurological and neuropathological approaches.<\/jats:p>","DOI":"10.1111\/neup.12767","type":"journal-article","created":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T05:21:38Z","timestamp":1632115298000},"page":"396-405","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Intravascular large <scp>B\u2010cell<\/scp> lymphoma affecting multiple cranial nerves: A histopathological study"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3025-4717","authenticated-orcid":false,"given":"Andrea","family":"Porzionato","sequence":"first","affiliation":[{"name":"Section of Human Anatomy, Department of Neuroscience University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Pelletti","sequence":"additional","affiliation":[{"name":"Section of Legal Medicine, Department of Medical and Surgical Sciences University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Barzon","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Contran","sequence":"additional","affiliation":[{"name":"Section of Human Anatomy, Department of Neuroscience University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aron","family":"Emmi","sequence":"additional","affiliation":[{"name":"Section of Human Anatomy, Department of Neuroscience University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Arminio","sequence":"additional","affiliation":[{"name":"Section of Legal Medicine, Department of Medical and Surgical Sciences University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Macchi","sequence":"additional","affiliation":[{"name":"Section of Human Anatomy, Department of Neuroscience University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"De Caro","sequence":"additional","affiliation":[{"name":"Section of Human Anatomy, Department of Neuroscience University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,19]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"444","article-title":"Intravascular lymphomatosis (malignant angioendotheliomatosis). A B\u2010cell neoplasm expressing surface homing receptors","volume":"1","author":"Ferry JA","year":"1988","journal-title":"Mod Pathol"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(00)80223-3"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-04-737445"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2010-0747-RS"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12300"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.05177.x"},{"key":"e_1_2_7_8_1","first-page":"252","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissue (IARC WHO Classification of Tumours)","author":"Nakamura S","year":"2008"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.5414\/NPP29233"},{"key":"e_1_2_7_10_1","first-page":"239","article-title":"Angiotropic large cell lymphoma with imaging characteristics of CNS vasculitis","volume":"23","author":"Song DK","year":"2002","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_7_11_1","first-page":"308","article-title":"Dominant neurologic symptomatology in intravascular large B\u2010cell lymphoma","volume":"117","author":"Kubisova K","year":"2016","journal-title":"Bratisl Lek Listy"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-009-0149-0"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/00207454.2012.760561"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.4322\/acr.2018.063"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/ajns.AJNS_243_17"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.03.006"},{"key":"e_1_2_7_17_1","first-page":"8947616","article-title":"Hemophagocytic syndrome\u2010associated variant of methotrexate\u2010associated intravascular large B\u2010cell lymphoma in a rheumatoid arthritis patient","volume":"2019","author":"Komeno Y","year":"2019","journal-title":"Case Rep Hematol"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-018-3481-8"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/1556-4029.14141"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/NRL.0000000000000042"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2005.01.001"},{"key":"e_1_2_7_22_1","first-page":"9625075","article-title":"Pituitary gland and neurological involvement in a case of Hemophagocytic syndrome revealing an intravascular large B\u2010cell lymphoma","volume":"2019","author":"Simeni Njonnou SR","year":"2019","journal-title":"Case Rep Hematol"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.28.6.476"},{"key":"e_1_2_7_24_1","first-page":"62","article-title":"Malignant lymphoma presenting with neoplastic angioendotheliosis of the central nervous system","volume":"2","author":"Yamamura Y","year":"1983","journal-title":"Clin Neuropathol"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850201)55:3<570::AID-CNCR2820550316>3.0.CO;2-0"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(86)33591-7"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19901015)66:8<1781::AID-CNCR2820660824>3.0.CO;2-5"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930515)71:10<3156::AID-CNCR2820711043>3.0.CO;2-O"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.32.237"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2010.01477.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26090"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2015.03.026"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12751"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000014470"},{"key":"e_1_2_7_35_1","first-page":"S2319\u20104170(20)3","article-title":"Intravascular large B\u2010cell lymphoma: A case series and review of literatures","author":"Ong YC","year":"2020","journal-title":"Biomed J"}],"container-title":["Neuropathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/neup.12767","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/neup.12767","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/neup.12767","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T16:37:24Z","timestamp":1692981444000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/neup.12767"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,19]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1111\/neup.12767"],"URL":"https:\/\/doi.org\/10.1111\/neup.12767","archive":["Portico"],"relation":{},"ISSN":["0919-6544","1440-1789"],"issn-type":[{"value":"0919-6544","type":"print"},{"value":"1440-1789","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,19]]},"assertion":[{"value":"2021-04-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}