{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:45:45Z","timestamp":1747187145041,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,9,19]],"date-time":"2021-09-19T00:00:00Z","timestamp":1632009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["grant\u2010in\u2010aid for scientific research 19K07820"],"award-info":[{"award-number":["grant\u2010in\u2010aid for scientific research 19K07820"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:p>A Japanese man in the present study experienced acute weakness in his right leg as a two year old. The strength in his leg gradually recovered and developed, and he could play golf and climb mountains up to around the age of 50. From approximately 55\u2009years of age, he became unable to stand up from a stooped position. Muscle weakness and atrophy spread to his right arm, and an electromyography revealed a neurogenic pattern in his lower and upper extremities. The patient was diagnosed as having post\u2010poliomyelitis syndrome (<jats:styled-content style=\"fixed-case\">PPS<\/jats:styled-content>). Numbness in both the legs and pain in the buttocks occurred after 60\u2009years of age. <jats:styled-content style=\"fixed-case\">Computed tomography<\/jats:styled-content> and magnetic resonance imaging at that time revealed spondylosis and protrusion of an osteophye in lower thoracic vertebrae compressing the second lumbar segment of the spinal cord. He died of malignant lymphoma and acute interstitial pneumonia at 80\u2009years of age. Pathological examination revealed transverse myelopathy at the second lumbar segment of the spinal cord and total necrosis. The anterior horn and the intermediate zone of the third and fourth lumbar segments of the spinal cord on the right side were atrophic and diffusely gliotic. An oval\u2010shaped plaque\u2010like lesion was observed in the right anterior horn at the third and fourth lumbar segments of the spinal cord. Neurons and synaptophysin immunoreactivity had completely disappeared in the plaque\u2010like lesion. A striking spread of vimentin\u2010immunoreactive cells was found corresponding to the lesion, while glial fibrillary acidic protein\u2010immunoreactive astrocytes existed evenly in the anterior horn and intermediate zone on both sides of the third and fourth lumber segments of the spinal cord. Virological examination using the autopsied materials was negative for poliovirus. Neither transactivation response DNA\u2010binding protein of 43 kDa\u2010immunoreactive inclusion nor Bunina body was seen in the spinal cord. The present paper demonstrates new findings of a noteworthy response of the vimentin\u2010immunoreactive cells within the peculiar \u201cplaque\u2010like lesion\u201d in the <jats:styled-content style=\"fixed-case\">PPS.<\/jats:styled-content><\/jats:p>","DOI":"10.1111\/neup.12768","type":"journal-article","created":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T02:37:30Z","timestamp":1632105450000},"page":"406-411","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Spread of vimentin\u2010immunoreactive cells within the plaque\u2010like lesion in the spinal anterior horn of a patient with post\u2010poliomyelitis syndrome"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1588-3654","authenticated-orcid":false,"given":"Akiyo","family":"Hineno","sequence":"first","affiliation":[{"name":"Department of Medicine (Neurology and Rheumatology) Shinshu University School of Medicine  Matsumoto Japan"},{"name":"Intractable Disease Care Center Shinshu University Hospital  Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5196-3489","authenticated-orcid":false,"given":"Kiyomitsu","family":"Oyanagi","sequence":"additional","affiliation":[{"name":"Department of Brain Disease Research Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8602-7455","authenticated-orcid":false,"given":"Takuhiro","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Medicine (Neurology and Rheumatology) Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7210-9249","authenticated-orcid":false,"given":"Yasuhiro","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathology 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