{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:17:49Z","timestamp":1787015869224,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T00:00:00Z","timestamp":1632355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:p>\n                    Ependymoma is a relatively rare glial tumor of the central nervous system that arise from the cells lining the ventricles and central canal of the spinal cord. Ependymosarcoma (ES) is a newly introduced tumor entity of uncertain prognosis characterized by a rare phenomenon of a malignant mesenchymal transition arising within an ependymoma. ESs are surgically challenging tumors for diagnosis and therapy with a high incidence of morbidity and mortality. Here, we report two diagnostically challenging cases of primary ES in a 25\u2010year\u2010old female and a 17\u2010year\u2010old male. Both the cases presented with progressive and sequential neurological deficits over a period of five to eight months, and histological examination revealed a biphasic gliomesenchymal architecture comprised of anaplastic ependymomatous and sarcomatous components. Molecular genetic analysis revealed the presence of type 1\n                    <jats:italic>C11orf95:RELA<\/jats:italic>\n                    fusion transcript. To date, 22 cases of ES have been reported in the literature, and only one case harbored type 1\n                    <jats:italic>C11orf95:RELA<\/jats:italic>\n                    fusion transcript.\n                  <\/jats:p>","DOI":"10.1111\/neup.12770","type":"journal-article","created":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T12:41:48Z","timestamp":1632487308000},"page":"412-421","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Ependymosarcoma harboring\n                    <i>\n                      C11orf95:\n                      <scp>RELA<\/scp>\n                    <\/i>\n                    fusion transcript: Report of two cases and review of the literature"],"prefix":"10.1111","volume":"41","author":[{"given":"Swati","family":"Mahajan","sequence":"first","affiliation":[{"name":"Department of Pathology All India Institute of Medical Sciences  New Delhi 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promoter mutations but not the alternative lengthening of telomeres phenotype are present in a subset of ependymomas and are associated with adult onset and progression to ependymosarcoma","volume":"76","author":"Br\u00fcgger F","year":"2017","journal-title":"J Neuropathol Exp 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