{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:45:47Z","timestamp":1747187147298,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,2,20]],"date-time":"2022-02-20T00:00:00Z","timestamp":1645315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003837","name":"Ichiro Kanehara Foundation for the Promotion of Medical Sciences and Medical Care","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003844","name":"Inamori Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003844","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K17673","20K09392","20K17972","21H03044","21K09128"],"award-info":[{"award-number":["19K17673","20K09392","20K17972","21H03044","21K09128"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:p>The mutation p.K27M in<jats:italic>H3F3A<\/jats:italic>(<jats:italic>H3<\/jats:italic>K27M mutation) is mainly detected in diffuse midline glioma. However, recent studies have demonstrated that<jats:italic>H3<\/jats:italic>K27M mutation could also be observed in a subset of gangliogliomas. Importantly, most<jats:italic>H3<\/jats:italic>K27\u2010mutated ganglioglioma cases also harbor<jats:italic>BRAF<\/jats:italic>V600E mutation. Herein, we report a rare case of<jats:italic>H3<\/jats:italic>K27M\u2010mutated ganglioglioma grade 3 without<jats:italic>BRAF<\/jats:italic>mutation arising in the medial temporal lobe in an elderly man. A small biopsy specimen was sampled. The pathological diagnosis was diffuse astrocytoma. The tumor progressed gradually during an 18\u2010month follow\u2010up period. Gadolinium enhancement on magnetic resonance imaging was noted 36\u2009months after the biopsy. The patient was referred to a hospital for tumor resection. Histological analysis of resected specimens led to a diagnosis of ganglioglioma grade 3 with H3 K27M mutation. The patient underwent concurrent temozolomide chemotherapy with radiotherapy. Although the patient's condition deteriorated after chemotherapy due to disease progression, he survived for more than 23\u2009months after tumor resection. We present this rare case and discuss the involvement of<jats:italic>H3<\/jats:italic>K27M mutation in ganglioglioma grade\u20093.<\/jats:p>","DOI":"10.1111\/neup.12793","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T01:09:35Z","timestamp":1645405775000},"page":"197-203","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A case of ganglioglioma grade 3 with<scp>H3 K27M<\/scp>mutation arising in the medial temporal lobe in an elderly patient"],"prefix":"10.1111","volume":"42","author":[{"given":"Yutaro","family":"Fujii","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Graduate School of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5636-8064","authenticated-orcid":false,"given":"Ryusuke","family":"Hatae","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Graduate School of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhiro","family":"Hata","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Graduate School of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi O.","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, Graduate School of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhei","family":"Sangatsuda","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Graduate School of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4393-1721","authenticated-orcid":false,"given":"Kosuke","family":"Takigawa","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Graduate School of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Funakoshi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Graduate School of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Fujioka","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Graduate School of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Kuga","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Graduate School of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Mizoguchi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Graduate School of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7826-870X","authenticated-orcid":false,"given":"Toru","family":"Iwaki","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, Graduate School of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7912-2024","authenticated-orcid":false,"given":"Koji","family":"Yoshimoto","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Graduate School of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1545-1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noab106"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlw074"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12473"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0160489"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12347"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.060954"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12759"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10833"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.1102"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2012.08.024"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/not144"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-014-1319-6"},{"key":"e_1_2_8_15_1","first-page":"vdaa142","article-title":"Clinical, radiologic, and genetic characteristics of histone H3 K27M\u2010mutant diffuse midline gliomas in adults","volume":"2","author":"Schulte JD","year":"2020","journal-title":"Neurooncol Adv"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2018.04.015"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0000000000000619"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-011-0615-4"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2017.09.011"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1082322"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-016-0353-0"},{"key":"e_1_2_8_22_1","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1002\/ijc.32258","article-title":"A pilot precision medicine trial for children with diffuse intrinsic pontine glioma\u2010PNOC003: A report from the Pacific pediatric Neuro\u2010oncology consortium","volume":"145","author":"Mueller S","year":"2019","journal-title":"Int J Cancer"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10014-019-00347-w"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12329"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12471"}],"container-title":["Neuropathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/neup.12793","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/neup.12793","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/neup.12793","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T20:28:46Z","timestamp":1700252926000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/neup.12793"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,20]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1111\/neup.12793"],"URL":"https:\/\/doi.org\/10.1111\/neup.12793","archive":["Portico"],"relation":{},"ISSN":["0919-6544","1440-1789"],"issn-type":[{"type":"print","value":"0919-6544"},{"type":"electronic","value":"1440-1789"}],"subject":[],"published":{"date-parts":[[2022,2,20]]},"assertion":[{"value":"2021-09-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}