{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:45:47Z","timestamp":1747187147472,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T00:00:00Z","timestamp":1646784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:p>Lymphomatosis cerebri (LC) is a rare variant of primary central nervous system lymphoma (PCNSL). It is characterized by diffuse infiltration of atypical lymphoid cells with no mass formation and little or no contrast enhancement on magnetic resonance imaging (MRI). Interestingly, some lymphoma cells form characteristic spindle shapes; these cells are found in some variants of malignant lymphoma, such as primary cutaneous follicle center lymphoma, but they have not been reported in PCNSL or LC. Here, we provide an autopsy case report of LC in a 69\u2010year\u2010old immunocompetent man who developed rapidly progressive cognitive decline and died on day 68 after the episode despite treatment with intravenous methylprednisolone administration. MRI revealed high signal intensities on T2\u2010weighted images of the cerebral hemispheres, cerebellum, brainstem, and spinal cord without gadolinium enhancement on T1\u2010weighted images. On autopsy, diffuse infiltrative atypical cells were seen; these cells were positive for CD20 and CD79a and negative for GFAP, CD3, and CD5 on immunohistochemistry, resulting in a diagnosis of diffuse large B\u2010cell lymphoma, specifically LC. We found characteristic spindle\u2010shaped cells, especially in the cerebral cortex. This is the first report showing that lymphoma cells in PCNSL can take on a spindle\u2010shaped form. It is difficult to recognize these spindle\u2010shaped cells as lymphoma cells on hematoxylin and eosin staining and diagnose them correctly with small biopsy specimens without immunohistochemistry. This case suggests that we should add atypical, spindle\u2010shaped cells to the differential diagnosis of PCNSL.<\/jats:p>","DOI":"10.1111\/neup.12796","type":"journal-article","created":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T05:55:46Z","timestamp":1646891746000},"page":"218-225","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Numerous spindle\u2010shaped lymphoma cells in lymphomatosis cerebri: An autopsy case report"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5725-1925","authenticated-orcid":false,"given":"Yu","family":"Mori","sequence":"first","affiliation":[{"name":"Department of Neurology Toyota Kosei Hospital  Toyota Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Tomita","sequence":"additional","affiliation":[{"name":"Department of Neurology Toyota Kosei Hospital  Toyota Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Hattori","sequence":"additional","affiliation":[{"name":"Department of Neurology Toyota Kosei Hospital  Toyota Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuko","family":"Ujihira","sequence":"additional","affiliation":[{"name":"Department of Pathology Toyota Kosei Hospital  Toyota Japan"},{"name":"Department of Pathology Hekinan Municipal Hospital  Hekinan Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michihiko","family":"Narita","sequence":"additional","affiliation":[{"name":"Department of Pathology Toyota Kosei Hospital  Toyota Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8520-6184","authenticated-orcid":false,"given":"Mari","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Institute for Medical Science of Aging Aichi Medical University  Nagakute Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,9]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"271","volume-title":"WHO Classification of Tumours of the Central Nervous System","author":"Deckert M","year":"2016"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000017116"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2016-216591"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.54.3283"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2014.12.003"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-014-1974-3"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2013-201246"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-011-5965-5"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.2011.01203.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.2009.01004.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2007.00044_2.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2005.01.014"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/0028-3886.273648"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nov197"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10014-011-0064-y"},{"key":"e_1_2_7_17_1","first-page":"282","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Willemze R","year":"2017"},{"key":"e_1_2_7_18_1","first-page":"4381","article-title":"Primary platelet\u2010derived growth factor\u2010producing, spindle\u2010shaped diffuse large B\u2010cell lymphoma of the skull: A case report and literature review","volume":"7","author":"Sugimoto K","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200008000-00001"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2012.01826.x"},{"key":"e_1_2_7_21_1","unstructured":"UjihiraN NaritaM MoriY et al.Spindle\u2010shaped B\u2010cell lymphoma cells in the central nervous system. (minute in Japanese with English title). The 58th Annual Meeting of The Japanese Society of Neuropathology 2017."},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.5858\/2002-126-0723-SVOALC"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001623"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000034256.20173.EA"},{"key":"e_1_2_7_25_1","first-page":"1463","article-title":"Neuroradiological features of lymphomatosis cerebri: A systematic review of the English literature with a new case report","volume":"18","author":"Li L","year":"2018","journal-title":"Oncol Lett"}],"container-title":["Neuropathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/neup.12796","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/neup.12796","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/neup.12796","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T06:50:54Z","timestamp":1692946254000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/neup.12796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,9]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1111\/neup.12796"],"URL":"https:\/\/doi.org\/10.1111\/neup.12796","archive":["Portico"],"relation":{},"ISSN":["0919-6544","1440-1789"],"issn-type":[{"type":"print","value":"0919-6544"},{"type":"electronic","value":"1440-1789"}],"subject":[],"published":{"date-parts":[[2022,3,9]]},"assertion":[{"value":"2021-09-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}