{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:45:47Z","timestamp":1747187147955,"version":"3.40.5"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T00:00:00Z","timestamp":1644883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:p>We report an autopsy case of multiple sclerosis (MS) manifesting as a long spinal cord lesion. The patient was a Japanese woman. At the age of 59\u2009years, she presented with a one\u2010month history of progressive paraplegia, dysesthesia in the lower extremities, and urinary retention. Magnetic resonance imaging revealed a long, hyperintense lesion on T2\u2010weighted images that extended from the inferior portion of the medulla oblongata to the cervical segments of the spinal cord and an isolated lesion at the T6 level. Cerebrospinal fluid (CSF) examination revealed the presence of oligoclonal bands and increased myelin basic protein levels (999 pg\/mL). Serum antibody against aquaporin 4 (AQP4) was undetectable in this patient. She was diagnosed as having atypical MS and experienced symptom improvement following immunotherapy with corticosteroids and plasma exchange. She died of pneumonia and renal failure at the age of 62\u2009years. Postmortem examination revealed a long demyelinating lesion that extended from the inferior portion of the medulla oblongata to the sacral segments of the spinal cord. The lesion was comprised of numerous demyelinating plaques with inflammatory cell infiltration. A long spinal cord lesion is usually indicative of neuromyelitis optica spectrum disorder (NMOSD), and there are limited reports of postmortem observations of long spinal cord lesions among patients with anti\u2010AQP4 antibody\u2010seronegative MS. Our findings suggest that the pathomechanisms of such long spinal cord lesion formation differ between anti\u2010AQP4 antibody\u2010seronegative MS and NMOSD.<\/jats:p>","DOI":"10.1111\/neup.12800","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T06:49:17Z","timestamp":1644994157000},"page":"212-217","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pathological observations of a long spinal cord lesion in a patient with multiple sclerosis"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3783-7077","authenticated-orcid":false,"given":"Hiroyuki","family":"Yabata","sequence":"first","affiliation":[{"name":"Department of Neuropathology Institute for Medical Science of Aging, Aichi Medical University  Nagakute Japan"},{"name":"Department of Neurology Shiga University of Medical Science  Otsu 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Neuropathology Institute for Medical Science of Aging, Aichi Medical University  Nagakute Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9057-7609","authenticated-orcid":false,"given":"Jun","family":"Sone","sequence":"additional","affiliation":[{"name":"Department of Neuropathology Institute for Medical Science of Aging, Aichi Medical University  Nagakute Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0723-0047","authenticated-orcid":false,"given":"Hiroaki","family":"Miyahara","sequence":"additional","affiliation":[{"name":"Department of Neuropathology Institute for Medical Science of Aging, Aichi Medical University  Nagakute Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manabu","family":"Doyu","sequence":"additional","affiliation":[{"name":"Department of Neurology Aichi Medical University School of Medicine  Nagakute 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