{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T07:44:14Z","timestamp":1778917454423,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,4,17]],"date-time":"2022-04-17T00:00:00Z","timestamp":1650153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:p>Progressive supranuclear palsy (PSP) with predominant frontal presentation (PSP\u2010F) is a clinical phenotype of PSP that is characterized by frontal cognitive impairment and behavioral changes. Here, we report on a patient with pathologically diagnosed PSP\u2010F in whom we were able to observe temporal changes of the clinical manifestations. A 77\u2010year\u2010old right\u2010handed man developed progressive nonfluent aphasia (PNFA) at the age of 69\u2009years, festinating gait, and clumsiness of his left arm at age 75, disinhibition at age 76, and unprovoked falls at age 77. Neurological examination at age 77 revealed limb\u2010kinetic apraxia of the left upper and lower limbs, rigidity, cortical sensory loss, and vertical supranuclear gaze palsy. According to the Movement Disorder Society clinical diagnostic criteria for PSP, his clinical manifestations shifted from suggestive PSP with predominant speech\/language disorder to probable PSP\u2010F over nine\u2009years. Cerebral atrophy on brain magnetic resonance imaging and decreased accumulation of <jats:sup>99m<\/jats:sup>Tc\u2010ECD on cerebral blood flow single\u2010photon emission computed tomography were noted with right side predominance. Pathologically, 4\u2010repeat tau\u2010immunoreactive globose\u2010type neurofibrillary tangles, coiled bodies, tufted astrocytes, and neuropil threads were observed predominantly in the frontal cortex. Tau pathology of the substantia nigra, locus coeruleus and subthalamic nucleus was mild. These findings suggested that localized tau pathology involving the pars opercularis extended to the precentral gyrus, prefrontal cortex, and brainstem. This case report demonstrates that PSP\u2010F can present as a PNFA due to crossed aphasia.<\/jats:p>","DOI":"10.1111\/neup.12805","type":"journal-article","created":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T05:48:47Z","timestamp":1650260927000},"page":"232-238","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Progressive supranuclear palsy with predominant frontal presentation exhibiting progressive nonfluent aphasia due to crossed aphasia"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6777-4252","authenticated-orcid":false,"given":"Yoya","family":"Ono","sequence":"first","affiliation":[{"name":"Department of Neurology Gifu University Graduate School of Medicine  Gifu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Higashida","sequence":"additional","affiliation":[{"name":"Department of Neurology Gifu University Graduate School of Medicine  Gifu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuaki","family":"Yoshikura","sequence":"additional","affiliation":[{"name":"Department of Neurology Gifu University Graduate School of Medicine  Gifu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4048-3513","authenticated-orcid":false,"given":"Yuichi","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Neurology Gifu University Graduate School of Medicine  Gifu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akio","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Neurology Gifu University Graduate School of Medicine  Gifu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0059-3104","authenticated-orcid":false,"given":"Yasushi","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Department of Neuropathology Institute for Medical Sciences of Aging, Aichi Medical University  Nagakute Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8520-6184","authenticated-orcid":false,"given":"Mari","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Neuropathology Institute for Medical Sciences of Aging, Aichi Medical University  Nagakute Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8788-9089","authenticated-orcid":false,"given":"Takayoshi","family":"Shimohata","sequence":"additional","affiliation":[{"name":"Department of Neurology Gifu University Graduate School of Medicine  Gifu 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\u201ccrossed\u201d aphasia and the factors which go to determine whether the \u201cleading\u201d or \u201cdriving\u201d speech\u2010centers shall be located in the left or in the right hemisphere of the brain: With notes of a case of \u201ccrossed\u201d aphasia (aphasia with right\u2010sided hemiplegia) in a left\u2010handed man","volume":"153","author":"Bramwell 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