{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:47:26Z","timestamp":1789706846640,"version":"4.0.1"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T00:00:00Z","timestamp":1653264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP21wm0425019"],"award-info":[{"award-number":["JP21wm0425019"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:p>Neurolymphomatosis is a neurological manifestation of lymphoma that involves  the cranial or spinal peripheral nerves, nerve roots, and plexus with direct invasion of neoplastic cells. Neurolymphomatosis is rare among patients with low\u2010grade lymphoma. We report an autopsied case of neurolymphomatosis that arose from follicular lymphoma. A 49\u2010year\u2010old woman who presented with pain of her neck and shoulder and numbness of her chin. Computed tomography revealed enlarged lymph nodes in her whole body, and biopsy from the axillary lymph node revealed grade 2 follicular lymphoma. Although the patient underwent chemotherapy, she gradually developed muscle weakness in the upper limbs and sensory disturbances of the trunk and limbs. <jats:sup>18<\/jats:sup>F\u2010fluorodeoxyglucose positron emission tomography (FDG\u2010PET) revealed increased tracer uptake of the cervical nerve roots. Repeated FDG\u2010PET after additional therapy revealed progression of disease within the nerve roots and brachial plexus, whereas gadolinium\u2010contrast magnetic resonance imaging (MRI) showed weak enhancement of the cervical nerve roots without formation of mass lesions. She died after a total disease duration of 12\u2009months. Postmortem observations revealed invasion of lymphoma cells into the cervical nerve roots, dorsal root ganglia, and subarachnoid spaces of the spinal cord. Neurolymphomatosis was prominent at the segments of C6\u2013Th2. Combined loss of axons and myelin sheaths was observed in the cervical nerve roots and posterior columns. Lymphoma cells also invaded the cranial nerves. The subarachnoid and perivascular spaces of the brain demonstrated focal invasion of the lymphoma. Mass lesions were not observed in the central nervous system. The lymphoma cells did not show histological transformation to higher grades, and the density of the centroblasts remained at grade 2. Our report clarifies that low\u2010grade follicular lymphoma can manifest as neurolymphomatosis and central nervous system invasion in the absence of transformation toward higher histological grades. FDG\u2010PET may be more sensitive to non\u2010mass\u2010forming lesions, including neurolymphomatosis, than gadolinium\u2010contrast MRI.<\/jats:p>","DOI":"10.1111\/neup.12807","type":"journal-article","created":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T05:59:12Z","timestamp":1653371952000},"page":"295-301","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Neurolymphomatosis in follicular lymphoma: an autopsy case report"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7045-7098","authenticated-orcid":false,"given":"Takashi","family":"Ando","sequence":"first","affiliation":[{"name":"Department of Neurology Nagoya University Graduate School of Medicine  Nagoya Japan"},{"name":"Department of Neuropathology Institute for Medical Science of Aging, Aichi Medical University  Nagakute 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