{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T03:07:43Z","timestamp":1780369663801,"version":"3.54.1"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,7,10]],"date-time":"2022-07-10T00:00:00Z","timestamp":1657411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:p>Pallido\u2010nigro\u2010luysian atrophy (PNLA) is a variant of progressive supranuclear palsy (PSP). Patients with PSP sometimes show psychiatric signs, but there are few reports about such signs being associated with PSP\u2010PNLA. Here, we report a case of PSP\u2010PNLA with argyrophilic grains (AGs) in a patient clinically diagnosed as having PSP\u2010frontotemporal dementia (PSP\u2010F). A 74\u2010year\u2010old man described as \u201ckind\u201d presented with impaired memory, irritability, and apathy. He showed levodopa\u2010resistant parkinsonism and postural instability. Brain magnetic resonance imaging revealed mild atrophy of the midbrain and right\u2010side\u2010dominant atrophy of the hippocampus and temporal lobe. The patient was diagnosed as having PSP with frontal lobe cognitive or behavioral presentations (PSP\u2010F). He died of aspiration pneumonia at age 81. At autopsy, macroscopic examination revealed depigmentation of the substantia nigra and grayish discoloration of the dentate nucleus, globus pallidus, and subthalamic nucleus. Severe gliosis was observed in the same regions. There were many phosphorylated tau\u2010immunoreactive equivocal tufted astrocytes in the globus pallidus. Many neurofibrillary tangles and neuropil threads were observed in the substantia nigra and subthalamic nucleus, and few tau aggregates were observed in the frontal cortex. In contrast, AGs were abundant in the amygdala, entorhinal cortex, and anterior cingulate gyrus, with an asymmetric distribution. The pathological observations led us to change the diagnosis to PSP\u2010PNLA with AGs. Although most cases of PSP\u2010F derive from tau pathology in the frontal cortex, this patient did not have phosphorylated tau\u2010immunoreactive aggregates in that location. Our observations suggest that the psychiatric signs of PSP\u2010F should be considered as being due to the presence of limbic AGs, not frontal tau pathology.<\/jats:p>","DOI":"10.1111\/neup.12815","type":"journal-article","created":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T06:26:16Z","timestamp":1657520776000},"page":"447-452","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["An autopsy case of progressive supranuclear palsy. Pallido\u2010nigro\u2010luysian type with argyrophilic grains clinically presenting with personality and behavioral changes"],"prefix":"10.1111","volume":"42","author":[{"given":"Yuki","family":"Suzuki","sequence":"first","affiliation":[{"name":"Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine Tottori University  Yonago Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4919-2325","authenticated-orcid":false,"given":"Tadashi","family":"Adachi","sequence":"additional","affiliation":[{"name":"Division of Neuropathology, Department of Brain and Neurosciences, Faculty of Medicine Tottori University  Yonago Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayuko","family":"Sakuwa","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine Tottori University  Yonago 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