{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T05:05:21Z","timestamp":1791867921602,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T00:00:00Z","timestamp":1662508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004423","name":"World Health Organization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004423","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:p>Diffuse leptomeningeal glioneuronal tumor (DLGNT) is a rare glioneuronal neoplasm newly included in the 2016 World Health Organization Classification of Tumors of the Central Nervous System. Owing to the wide spectrum of its histopathological and radiological features, accurate diagnosis can be challenging. Recently, molecular testing including DNA methylation array has been introduced with the possibility of improving diagnostic accuracy and contributing to the subtyping especially for brain tumors with ambiguous histology. Two molecularly distinct subtypes of DLGNT have been reported: methylation class\u20101 (MC\u20101) with an indolent clinical course and MC\u20102, the latter aggressive. Herein, we report a case of a 14\u2010year\u2010old girl with a conspicuous hypothalamic mass lesion and diffuse leptomeningeal enhancement on magnetic resonance imaging. Biopsy specimens obtained from the hypothalamic lesion endoscopically were mainly composed of oligodendrocyte\u2010like cells. However, it was difficult to make a definite diagnosis from these non\u2010specific histological findings. Thus, DNA methylation array analysis was performed additionally by using formalin\u2010fixed, paraffin\u2010embedded tissue, resulting in a diagnosis of \u201cMC\u20101 subtype of DLGNT\u201d with a high calibrated score (0.99). Consequently, she was treated conservatively, with neither progression of the tumor nor aggravation of symptoms for the next 12\u2009months. It was concluded that DNA methylation array analysis for DLGNT, a rare glioneuronal tumor, could be a powerful tool not only for accurate diagnosis but also decision\u2010making in selecting the best treatment.<\/jats:p>","DOI":"10.1111\/neup.12818","type":"journal-article","created":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T05:05:37Z","timestamp":1662613537000},"page":"512-518","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>DNA<\/scp> methylation array analysis for diffuse leptomeningeal glioneuronal tumor with conspicuous hypothalamic mass. A case report"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9770-2425","authenticated-orcid":false,"given":"Seiji","family":"Yamada","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Nagoya City University Graduate School of Medical Sciences  Nagoya Aichi Japan"},{"name":"Department of Diagnostic Pathology Fujita Health University School of Medicine  Toyoake Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoki","family":"Tanikawa","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Nagoya City University Graduate School of Medical Sciences  Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Shibata","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Nagoya City University Graduate School of Medical Sciences  Nagoya Aichi 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