{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:45:52Z","timestamp":1747187152490,"version":"3.40.5"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,10,9]],"date-time":"2022-10-09T00:00:00Z","timestamp":1665273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100016342","name":"Ministry of Health Mexico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016342","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["20FC1030"],"award-info":[{"award-number":["20FC1030"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006004","name":"Tohoku University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006004","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:p>Here, we report a case of IgG4\u2010related brain pseudotumor (IgG4\u2010BP) in a 39\u2010year\u2010old woman, mimicking central nervous system (CNS) lymphoma. She presented with headache, fever, and fatigue. Her medical history was notable for appearance of a tumefactive brain lesion seven years before. Brain biopsy performed at the age of 32 revealed nonspecific inflammatory changes, and her condition improved with oral low\u2010dose steroid therapy. Magnetic resonance imaging performed at the age of 39\u2009identified a hyperintensity lesion with edema located at the medial temporal lobe region adjacent to the inferior horn of the left lateral ventricle on fluid\u2010attenuated inversion recovery images, which showed gadolinium\u2010contrast enhancement on T1\u2010weighted images and a slightly hyperintensity signal on diffusion\u2010weighted images. Methionine\u2010positron emission tomography (PET) depicted a high methionine uptake in the lesion. Additionally, soluble levels of interleukin (IL)\u20102 receptor (sIL\u20102R) and IL\u201010 were increased in cerebrospinal fluid (CSF). Based on these findings, we suspected CNS lymphoma and performed partial resection of the brain lesion. Pathological examination revealed prominent lymphocytic infiltration associated with plasma cell infiltration. Most of the plasma cells were immunoreactive for IgG4. Storiform fibrosis and partially obliterative phlebitis were concomitantly observed. Thus, the patient was diagnosed as having IgG4\u2010BP. To the best of our knowledge, this is the first case report of IgG4\u2010BP with detailed findings obtained by CSF testing, methionine\u2010PET, and pathological examination. Because IgG4\u2010related diseases can present as a pseudotumor that mimics CNS lymphoma, it is essential to carefully differentiate IgG4\u2010BP from CNS lymphoma.<\/jats:p>","DOI":"10.1111\/neup.12839","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T11:46:28Z","timestamp":1665402388000},"page":"526-533","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>IgG4<\/scp>\u2010related brain pseudotumor mimicking <scp>CNS<\/scp> lymphoma. A case report"],"prefix":"10.1111","volume":"42","author":[{"given":"Rie","family":"Oshima","sequence":"first","affiliation":[{"name":"Departments of Neurology Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1197-1705","authenticated-orcid":false,"given":"Ryotaro","family":"Ikeguchi","sequence":"additional","affiliation":[{"name":"Departments of Neurology Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sho","family":"Wako","sequence":"additional","affiliation":[{"name":"Departments of Neurology Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takafumi","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Departments of Neurology Tokyo Women's Medical University  Tokyo 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