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The concept of long\u2010term epilepsy\u2010associated tumors (LEATs) includes a heterogenous group of low\u2010grade, cortically based tumors, associated to drug\u2010resistant epilepsy, often requiring surgical treatment. LEATs entities can sometimes be poorly discriminated by histological features, precluding a confident classification in the absence of additional diagnostic tools. This study aimed to provide an updated review on the genomic findings and DNA methylation profiling advances in LNETs, including histological entities of LEATs. A comprehensive search strategy was conducted on PubMed, Embase, and Web of Science Core Collection. High\u2010quality peer\u2010reviewed original manuscripts and review articles with full\u2010text in English, published between 2003 and 2022, were included. Results were screened based on titles and abstracts to determine suitability for inclusion, and when addressed the topic of the review was screened by full\u2010text reading. Data extraction was performed through a qualitative content analysis approach. Most LNETs appear to be driven mainly by a single genomic abnormality and respective affected signaling pathway, including <jats:italic>BRAF<\/jats:italic> p.V600E mutations in ganglioglioma, <jats:italic>FGFR1<\/jats:italic> abnormalities in dysembryoplastic neuroepithelial tumor, <jats:italic>MYB<\/jats:italic> alterations in angiocentric glioma, <jats:italic>BRAF<\/jats:italic> fusions in pilocytic astrocytoma, <jats:italic>PRKCA<\/jats:italic> fusions in papillary glioneuronal tumor, between others. However, these molecular alterations are not exclusive, with some overlap amongst different tumor histologies. Also, clustering analysis of DNA methylation profiles allowed the identification of biologically similar molecular groups that sometimes transcend conventional histopathological classification. The exciting developments on the molecular basis of these tumors reinforce the importance of an integrative histopathological and (epi)genetic classification, which can be translated into precision medicine approaches.<\/jats:p>","DOI":"10.1111\/neup.12846","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T06:20:26Z","timestamp":1658125226000},"page":"467-482","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The landscape of common genetic drivers and <scp>DNA<\/scp> methylation in low\u2010grade (epilepsy\u2010associated) neuroepithelial tumors: A review"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0197-6780","authenticated-orcid":false,"given":"Joana","family":"Jesus\u2010Ribeiro","sequence":"first","affiliation":[{"name":"Neurology Department Centro Hospitalar de Leiria  Leiria Portugal"},{"name":"Coimbra Institute for Clinical and 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