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In the present study, we performed immunohistochemistry (IHC) to probe the expression of the receptor for advanced glycation end products (RAGE); its key ligands, high\u2010mobility group box 1 (HMGB1), S100 calcium\u2010binding protein B (S100B), and <jats:italic>carboxymethyl\u2010<\/jats:italic>lysine (CML \u2013 advanced glycation end products (AGE)); and its cytoplasmic tail\u2010binding partner, diaphanous related formin 1 (DIAPH1) and associated molecules, beta\u2010actin (ACTB) and profilin 1 (PFN1) proteins in sciatic nerves harvested from seven\u2010month old FVB\/OVE26 mice with genetically\u2010mediated T1D. We found that the amount of RAGE, HMGB1, and S100B proteins was elevated in diabetic <jats:italic>vs<\/jats:italic> the non\u2010diabetic groups, while the amount of DIAPH1, ACTB, as well as PFN1 proteins did not differ between these groups. Moreover, our data revealed linear dependence between RAGE and HMGB1 proteins. Interaction criss\u2010cross of selected sets of proteins in the sciatic nerve revealed that there were connected in a singular network. Our results indicate that T1D may alter expression patterns of RAGE axis proteins and thus contribute to DLDN.<\/jats:p>","DOI":"10.1111\/neup.12852","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T06:05:15Z","timestamp":1659420315000},"page":"84-94","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The receptor for advanced glycation end products and its ligands\u2019 expression in <scp>OVE26<\/scp> diabetic sciatic nerve during the development of length\u2010dependent neuropathy"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6577-7545","authenticated-orcid":false,"given":"Kamila","family":"Zglejc\u2010Waszak","sequence":"first","affiliation":[{"name":"Department of Human Physiology and Pathophysiology University of Warmia and Mazury in Olsztyn, School of Medicine, Collegium Medicum  Olsztyn 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