{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:45:55Z","timestamp":1747187155167,"version":"3.40.5"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T00:00:00Z","timestamp":1667433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:p>Here, we describe two patients who presented with focal cortical signs and underwent neuropathological examination. Case 1 was a 73\u2010year\u2010old woman with progressive speech disorder and abnormal behavior. She showed agraphia of the frontal lobe type, featured by the omission of kana letters when writing, other than pyramidal tract signs, pseudobulbar palsy, and frontal lobe dementia. Neuropathological examination, including TAR DNA\u2010binding protein 43 (TDP\u201043) immunohistochemistry, revealed bilateral frontal and anterior temporal lobe lesions accentuated in the precentral gyrus and posterior part of the middle frontal gyrus. Both upper and lower motor neurons showed pathological changes compatible with amyotrophic lateral sclerosis. Case 2 was a 62\u2010year\u2010old man with progressive speech disorder and hand clumsiness. He had a motor speech disorder, compatible with apraxia of speech, and limb apraxia of the limb\u2010kinetic and ideomotor type. Neuropathological examination revealed degeneration in the left frontal lobe, including the precentral gyrus, anterior temporal, and parietal lobe cortices. Moreover, numerous argyrophilic neuronal intracytoplasmic inclusions (Pick body) and ballooned neurons were observed in these lesions and the limbic system. The pathological diagnosis was Pick disease involving the peri\u2010Rolandic area and parietal lobe. In these two cases, the distribution of neuropathological changes in the cerebral cortices correlated with the clinical symptoms observed.<\/jats:p>","DOI":"10.1111\/neup.12854","type":"journal-article","created":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T02:15:46Z","timestamp":1667528146000},"page":"27-43","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Symptomatology and Neuropathology of patients presenting with focal cortical signs"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7027-6243","authenticated-orcid":false,"given":"Kenji","family":"Ishihara","sequence":"first","affiliation":[{"name":"Department of Neurology Showa University School of Medicine Tokyo Japan"},{"name":"Asahi Hospital of Neurology and Rehabilitation Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiya","family":"Fukui","sequence":"additional","affiliation":[{"name":"Department of Neurology Showa University School of Medicine Tokyo Japan"},{"name":"Kawasaki Memorial Hospital Kawasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuru","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Department of Neurology Showa University School of Medicine Tokyo Japan"},{"name":"Okusawa Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun\u2010ichi","family":"Shiota","sequence":"additional","affiliation":[{"name":"Department of Neurology Showa University School of Medicine Tokyo Japan"},{"name":"Ushioda Home Clinic Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imaharu","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Neurology Jichi Medical University Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,3]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"181","article-title":"Pathology of dementia (in Japanese with English abstract)","volume":"37","author":"Ishihara K","year":"2021","journal-title":"Shinkei Shinrigaku"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/146912"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.11.1621"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2466\/pms.1994.79.1.664"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-011-0845-8"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.2.467"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.6.1546"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/814846"},{"key":"e_1_2_6_10_1","first-page":"673","article-title":"A case of dementia with motor neuron disease associated with agraphia \u2013 the omission of kana letters \u2013 (in Japanese with English abstract)","volume":"44","author":"Kanzaki M","year":"2004","journal-title":"Rhinsho Shinkeigaku"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0093-934X(77)90032-3"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-009-5136-0"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.176999"},{"key":"e_1_2_6_14_1","first-page":"92","volume-title":"Clinical Neuropsychology","author":"Marcie P","year":"1979"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e31815c3486"},{"volume-title":"Unterschingen \u00fcber die Localisation der Functionen in der Gr\u00f6sshirnrinde des Menschen","year":"1881","author":"Exner S","key":"e_1_2_6_16_1"},{"volume-title":"Their Value in Cerebral Localization","year":"1946","author":"Agnosia NJ","key":"e_1_2_6_17_1"},{"key":"e_1_2_6_18_1","first-page":"526","article-title":"A case of brain tumor at the base of the second left frontal convolution","volume":"117","author":"Gordinier HC","year":"1899","journal-title":"Am J Med Sci"},{"key":"e_1_2_6_19_1","first-page":"505","article-title":"Agraphie pure (dynamique?) d'origine frontale. 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