{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:48:09Z","timestamp":1781657289888,"version":"3.54.5"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T00:00:00Z","timestamp":1660089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:p>Granulomatous hypophysitis is a rare and poorly understood condition. Although certain cases are treated as primary pituitary autoimmune disorders, rare cases may be associated with pituitary neuroendocrine tumours (PitNETs) and systemic inflammatory diseases. Here, we report a case of a 47\u2010year\u2010old man that underwent endoscopic trans\u2010sphenoidal excision of a pituitary mass diagnosed as PitNET. On histologic evaluation, the neoplasm showed an admixture of granulomas with extensive inflammatory infiltrate and lactotroph PitNET\/adenoma. Careful anamnestic examination revealed a diagnosis of Crohn's disease 20\u2009years prior. Although rarely done, both PitNET and Crohn's disease may be associated with granulomatous hypophysitis, and our patient had both conditions. During the 6\u2010year follow\u2010up, PitNETs and hypophysitis did not recur, while Crohn's disease was only partially controlled by medical therapy. To our knowledge, this is the first description of association of granulomatous hypophysitis, PitNET and Crohn's disease.<\/jats:p>","DOI":"10.1111\/neup.12857","type":"journal-article","created":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T04:59:29Z","timestamp":1660193969000},"page":"104-109","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Lactotroph <scp>PitNET<\/scp>\/adenoma associated to granulomatous hypophysitis in a patient with Crohn's disease: A case report"],"prefix":"10.1111","volume":"43","author":[{"given":"Alberto","family":"Pietrantoni","sequence":"first","affiliation":[{"name":"Pathology Unit, Department of Molecular and Translational Medicine University of Brescia and Pathology Service Spedali Civili of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Serioli","sequence":"additional","affiliation":[{"name":"Neurosurgery, Department of Surgical Specialties, Radiological Sciences and Public Health University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Cominelli","sequence":"additional","affiliation":[{"name":"Pathology Unit, Department of Molecular and Translational Medicine University of Brescia and Pathology Service Spedali Civili of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Lodoli","sequence":"additional","affiliation":[{"name":"Neuroradiology, Spedali Civili of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Stefini","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, ASST West Milan \u2010 Legnano Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Villanacci","sequence":"additional","affiliation":[{"name":"Pathology Unit, Department of 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